Alpinia oxyphylla Fruit Extract Ameliorates Experimental Autoimmune Encephalomyelitis through the Regulation of Th1/Th17 Cells

Figure 5

Effects of AO-1 on Th1 and Th17 cell regulation. (a) mRNAs expression of T-bet and RORγt in the spinal cord, (b) mRNAs expression of IFN-γ and IL-17 in the spinal cord, and (c) protein expression levels of T-bet and RORγt in the spleen. On Day 21 after MOG35–55 immunization, the spinal cords and spleens of untreated vehicle and AO-1-treated mice were harvested. The mRNA and protein expression levels were analyzed through qPCR and Western blot analysis. Data are expressed as mean ± SEM (n = 4). P < 0.05 and P < 0.001 compared with vehicle group.

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