Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Tab 1

Research Article

Assessment of the Effectiveness of Vitamin Supplement in Treating Eczema: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the included studies.

First author year (Reference)CountryStudy designSample size (I vs. C)Inclusion criteriaExclusion criteriaInterventionControlMain outcomeMean change (I vs. C)

Amestejani 2012 [11]IranRCT29 vs. 24Age 14 and older, with no concomitant pyretic, systemic disease or inflammatory processes1Pregnancy, concomitant systemic inflammatory disorder1, and use of vitamins, minerals and fatty acids supplements, oral contraceptive pills, antiepileptic agents, steroid hormones2, anticoagulant drugs1600 IU vitamin D3 60 daysPlacebo filled with starch identical in size and colorSCORAD−9.5, −1.84
Javanbakht 2011 [12]IranRCTGD3: 12
GE4: 11
GDE5: 11 vs.
GP6: 11
Patients with SCORAD from 10 to 70Patients taking vitamins, minerals and fatty acids supplements, oral contraceptive pills, steroid hormones2, antiepileptic agents, anticoagulant drugs, and pregnant or nursing mothersGD3: 1600 IU vitamin D3 and vitamin E placebo daily; GE4: 600 IU vitamin E and vitamin D3 placebo daily; GDE5: 1600 IU vitamin D3 and 600 IU vitamin E placebo daily 60 daysVitamin D3 placebo filled with starch, vitamin E placebo filled with mineral oilSCORADGD3: −12.7, −9.4
GE4: −12.9, −9.4
GDE5: −23.1, −9.4
Sanchez Armendariz 2018 [13]MexicoRCT29 vs. 29Patients diagnosed with moderate-severe ADPatients with primary immunodeficiency, renal tubular acidosis, and pregnancy and those taking other supplements, as well as lack of follow-up at 12 weeks5000 IU vitamin D3 daily for 3 monthsCelluloseSCORAD−21.2, −13.9
Lara-Corrales 2018 [14]CanadaRCT21 vs. 24Patients aged between 0 and 18 with a clinical diagnosis of ADPatients with known renal or liver disease or chronic dermatological conditions other than AD2000 IU vitamin D3 (2 drops of vitamin D3, 1000 IU/drop) daily for 3 monthsIdentical-appearing placebo dropsSCORAD−15.4, −15.3
Januchowski 2009 [15]AmericaRCT21 vs. 21Children aged 6 months to 18 years with eczema and the ability to understand the consent processUnwillingness of the parents to consent to the study protocol; pregnancy or lactation; eczema with superinfection present; known history of allergy to vitamin B12 or components of the base cream; topical treatment with corticosteroids in the 4 weeks prior to enrollment; or inability to speak and read English0.07% vitamin B12 twice a day for 4 weeksThe same moisturizing base without vitamin B12SCORAD−4.52, −1.61
Jaffary 2015 [16]IranRCT33 vs. 32Patients aged 10–50 years with a clinical diagnosis of ADSevere disease, requiring hospitalization, pregnant women, nursing mothers, coagulopathies, use of anticoagulant medications, systemic corticosteroids or immunosuppressants, as well as having a history of allergy to vitamin E, and living in long distances from Isfahan city; those patients who showed severe allergic symptoms to vitamin E and those who became pregnant during the therapy400 IU vitamin E daily 4 months oralPlacebo with no active ingredient and without smellSCORAD−11.12, −3.89
Sidbury 2008 [17]AmericaRCT5 vs. 6UnclearUnclear1000 IU vitamin D2 daily for 1 monthIdentical looking placeboEASI−4.6, −2.2
Camargo 2014 [18]MongoliaRCT57 vs. 47Patients aged 2–17 years with winter-related ADPatients with an active skin infection1000 IU vitamin D3 daily for 1 monthColorless, odorless and tasteless placeboEASI−6.5, −3.3
Galli 2015 [19]ItalyRCT41 vs. 48Children with chronic eczema (48 boys) with a median age of 68 months (range 6–195 months), with a clinical diagnosis of ADUnclear2000 IU vitamin D3 daily for 3 monthsNo vitamin D3 supplementationSCORAD−0.2, −1.3
Nistico 2017 [20]ItalyRCT22 vs. 22Male or female Caucasian patients with a confirmed clinical diagnosis of mild AD measured with total SCORAD Index up to 25 pointsUnclear0.07% vitamin B12 imbedded in a polysorbate carrier system 3 times a day for 12 weeksGlycerol-petrolatum-based emollient creamSCORAD−4.65, −1.09

1Other than diabetic mellitus and chronic viral hepatitis. 2Oral or parenteral. 3Vitamin D3 supplement group. 4Vitamin E supplement group. 5Vitamin D3 and vitamin E supplements in combined group. 6Placebo group.

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