Effect of Short-Course Oral Ciprofloxacin on Isoflavone Pharmacokinetics following Soy Milk Ingestion in Healthy Postmenopausal Women

Table 5

Pharmacokinetic parameters of daidzein obtained from 11 subjects receiving a single oral administration of soy milk (SOY Phase) and a short-course oral ciprofloxacin followed by a single oral administration of soy milk (CIPRO/SOY phase).

Pharmacokinetic parameters	Daidzein
	SOY phase		CIPRO/SOY phase
	Mean±SD	Median (IQR)	Mean±SD	Median (IQR)
(ng/mL)	833.12±351.17	752.60 (298.52)	511.17±243.7	497.19 (323.01
(h)	6.36±1.21	6.00 (1.00)	6.55±1.29	6.00 (2.00)
(ng.h/mL)	8553.84±5424.86	6826.87 (5759.28)	5977.10±4256.7	5599.80 (4391.67
(ng.h/mL)	9431.94±5411.69	7254.24 (4777.05)	6746.22±4403.3	6003.36 (4164.71
t1/2 (h)	6.52±1.89	6.23 (1.64)	6.42±2.07	6.36 (1.45)

Data represent mean±SD and median (interquartile range, IQR). <0.05 versus SOY phase using a paired t-test. <0.05 versus SOY phase using Wilcoxon’s signed-rank test.