Pilose Antler Extracts (PAEs) Protect against Neurodegeneration in 6-OHDA-Induced Parkinson’s Disease Rat Models

Figure 2

PAEs upregulated the levels of DA and its metabolites in CSF and striatum of PD rats model. HPLC-MS was used to measure DA, DOPAC, and HAV levels. (a) 6-OHDA decreased DA, HAV, and DOPAC levels in CSF of rats, while 60 mg/kg·d and 180 mg/kg·d PAEs administration increased DA, HAV, and DOPAC levels in CSF, but not significant. (b) 6-OHDA decreased DA, HAV and DOPAC levels in striatum of rats, while 60 mg/kg·d and 180 mg/kg·d PAEs administration increased DA, HAV, and DOPAC levels in striatum, but not significant (p<0.05 versus model, p<0.01 versus model).

(a)

(b)