Pilose Antler Extracts (PAEs) Protect against Neurodegeneration in 6-OHDA-Induced Parkinson’s Disease Rat Models

Figure 6

PAEs protect neuronal cells against 6-OHDA induced neurotoxicity. (a) HE staining showed that PAEs inhibited 6-OHDA induced neuronal cell death in the SNc. 6-OHDA administration significantly induced neuronal cell apoptosis. Administration of 60 mg/kg·d and 180 mg/kg·d PAEs inhibited neuronal cell apoptosis induced by 6-OHDA and its inhibition was higher compared to 10 mg/kg·d Madopar administration. (b) TH immunostaining demonstrated that PAEs could inhibit 6-OHDA induced TH-positive cell death in the SNc. TH-positive cells were reduced in 6-OHDA lesions in the SNc. Administration of 60 mg/kg·d and 180 mg/kg·d PAEs inhibited cell death induced by 6-OHDA, and its effect was comparable to 10 mg/kg·d Madopar treatment.