Safety of Aqueous Extract of Calea ternifolia Used in Mexican Traditional Medicine

Table 2

Parameters evaluated in the blood of male Wistar rats after exposure to the different treatments after 7 d

Parameter	Rifampin 8.5 mg/kg (positive control)	H2O (negative control)	C. ternifolia
			8.5 mg/kg	3.75 mg/kg	1.25 mg/kg
WBC (10^−3)	5.0 ± 1.6	12.0 ± 1.9	4.3 ± 0.3	2.5 ± 0.9	3.9 ± 1.2
PLT (10^−3)	294.3 ± 24.2	900.0 ± 3.9	418.0 ± 17.7	227 ± 10.2	193 ± 5.6
Urea (mg/dL)	69.5 ± 5.7	41.2 ± 5.9	57.8 ± 9.0	ND	ND
AST IU	85.0 ± 2.0	34.0 ± 2.3	546.0 ± 10.9	827 ± 4.7	212 ± 1.2
ALT IU	375.0 ± 1.5	50.0 ± 3.5	196.0 ± 21.1	548 ± 11.5	220 ± 9.6
F ALK IU	376.0 ± 5.0	33.0 ± 3.8	386.0 ± 5.7	697 ± 6.3	457 ± 4.9

WBC: leukocytes, PLT: platelets, ALT: alanine aminotransferase, AST: aspartate aminotransferase, ALP: alkaline phosphatase, IU: international units, ND: no determinate, and SD: ±. All the treatments have significant difference against the negative control, .