Research Article
Network Pharmacology and Bioinformatics Approach Reveals the Therapeutic Mechanism of Action of Baicalein in Hepatocellular Carcinoma
Table 1
Differently expressed genes from GSE95504.
| | Gene | | AveExpr | t | P-Value | adj. P-Value | B |
| | FAM129A | 2.624683 | 7.781198 | 21.34116 | 3.19E-08 | 0.000375 | 8.410651 | | ASNS | 2.267513 | 7.745739 | 25.81981 | 7.31E-09 | 0.000226 | 9.168015 | | DDIT3 | 2.158061 | 5.129843 | 20.13082 | 5.00E-08 | 0.000441 | 8.148515 | | SLC7A11 | 1.940169 | 8.499572 | 6.547421 | 0.000196 | 0.022113 | 1.219042 | | CTH | 1.859453 | 6.75212 | 17.32877 | 1.58E-07 | 0.000828 | 7.413078 | | SLFN5 | 1.77625 | 7.65223 | 11.24138 | 4.16E-06 | 0.004075 | 4.860584 | | ULBP1 | 1.734087 | 5.290091 | 14.11018 | 7.56E-07 | 0.001523 | 6.270654 | | OSBPL6 | 1.721142 | 5.858125 | 18.94741 | 7.97E-08 | 0.000586 | 7.861891 | | PSAT1P4 | 1.708273 | 7.674072 | 11.01701 | 4.83E-06 | 0.004101 | 4.729785 | | CLDN1 | 1.63562 | 6.888961 | 14.4617 | 6.27E-07 | 0.001383 | 6.414871 | | GDF15 | 1.610927 | 6.988729 | 12.48127 | 1.90E-06 | 0.002583 | 5.525689 | | CLGN | 1.536074 | 4.371125 | 18.84393 | 8.31E-08 | 0.000586 | 7.835261 | | TRIB3 | 1.535661 | 7.709365 | 17.24218 | 1.64E-07 | 0.000828 | 7.386996 | | TUBE1 | 1.515188 | 5.96114 | 15.58245 | 3.56E-07 | 0.00132 | 6.840486 | | ERRFI1 | 1.482139 | 7.451778 | 21.4253 | 3.09E-08 | 0.000375 | 8.427814 | | GPR1 | 1.471302 | 4.486647 | 13.82075 | 8.84E-07 | 0.001541 | 6.147765 | | GFPT1 | 1.462896 | 8.845707 | 17.25109 | 1.64E-07 | 0.000828 | 7.389692 | | PXK | 1.447934 | 5.986157 | 13.87282 | 8.59E-07 | 0.001541 | 6.170157 | | PSAT1 | 1.443356 | 10.30946 | 13.75243 | 9.18E-07 | 0.001541 | 6.118191 | | NFIL3 | 1.438356 | 6.135237 | 7.852097 | 5.60E-05 | 0.011763 | 2.454479 | | PMAIP1 | 1.319246 | 6.572005 | 12.40886 | 1.99E-06 | 0.002647 | 5.489364 | | CHAC1 | 1.30625 | 7.242645 | 9.979721 | 1.00E-05 | 0.005625 | 4.078163 | | C15orf65 | 1.290543 | 6.123697 | 6.54843 | 0.000196 | 0.022113 | 1.220081 | | GADD45A | 1.289319 | 7.282376 | 16.76291 | 2.04E-07 | 0.000958 | 7.238494 | | WARS | 1.275291 | 9.228478 | 12.87648 | 1.51E-06 | 0.002159 | 5.718873 | | SEL1L3 | 1.274108 | 7.258999 | 9.408758 | 1.54E-05 | 0.006705 | 3.683429 | | STC2 | 1.238835 | 6.081823 | 15.4665 | 3.77E-07 | 0.001328 | 6.798729 | | SLC22A15 | 1.22956 | 6.064722 | 13.9939 | 8.05E-07 | 0.001541 | 6.221742 | | CTAGE5 | 1.220954 | 6.554274 | 11.07457 | 4.64E-06 | 0.004075 | 4.763668 | | JAG1 | 1.214166 | 5.838658 | 8.328888 | 3.69E-05 | 0.009608 | 2.856702 | | SESN2 | 1.19303 | 7.048649 | 10.73854 | 5.83E-06 | 0.004571 | 4.562614 | | PHGDH | 1.18876 | 7.266541 | 11.47118 | 3.58E-06 | 0.003764 | 4.991071 | | GARS | 1.184448 | 9.965868 | 14.75109 | 5.40E-07 | 0.001333 | 6.529612 | | SGTB | 1.173656 | 5.908581 | 7.658115 | 6.68E-05 | 0.013087 | 2.283709 | | MOCOS | 1.16865 | 8.951834 | 15.92122 | 3.02E-07 | 0.001224 | 6.959663 | | PDE10A | 1.122733 | 6.077276 | 14.89259 | 5.02E-07 | 0.001333 | 6.584453 | | RND3 | 1.118622 | 6.761436 | 13.61063 | 9.92E-07 | 0.001591 | 6.056112 | | PCK2 | 1.11477 | 6.688267 | 15.34161 | 4.01E-07 | 0.001333 | 6.753186 | | ARG2 | 1.109017 | 5.776241 | 7.100543 | 0.000113 | 0.016946 | 1.768427 | | CCDC113 | 1.10665 | 6.174742 | 7.187338 | 0.000104 | 0.016349 | 1.851102 | | ZNF252P | 1.100149 | 6.009432 | 5.675607 | 0.000504 | 0.03647 | 0.26837 | | CARS | 1.082632 | 6.759968 | 14.92228 | 4.94E-07 | 0.001333 | 6.595858 | | ETV5 | 1.080051 | 6.215242 | 9.459451 | 1.48E-05 | 0.00668 | 3.719593 | | AARS | 1.075095 | 10.13323 | 12.06077 | 2.46E-06 | 0.002893 | 5.310541 | | NR1D2 | 1.069287 | 6.525232 | 6.13772 | 0.000302 | 0.02816 | 0.785742 | | PYROXD1 | 1.064665 | 7.7943 | 6.357469 | 0.000239 | 0.024807 | 1.021033 | | TRIM2 | 1.063894 | 6.068377 | 14.25706 | 6.99E-07 | 0.001449 | 6.331573 | | XPOT | 1.052345 | 9.70088 | 8.58299 | 2.98E-05 | 0.008532 | 3.061361 | | HERPUD1 | 1.051263 | 8.736178 | 14.36397 | 6.60E-07 | 0.001411 | 6.375315 | | XBP1 | 1.043021 | 7.951268 | 13.68627 | 9.52E-07 | 0.001561 | 6.089348 | | SARS | 1.039932 | 8.565683 | 12.23496 | 2.21E-06 | 0.002784 | 5.400901 | | ACAD11 | 1.036179 | 5.605899 | 14.46101 | 6.27E-07 | 0.001383 | 6.414591 | | TSEN15 | 1.027667 | 6.697341 | 9.904686 | 1.06E-05 | 0.005645 | 4.02783 | | BMP6 | 1.020646 | 8.133826 | 9.363714 | 1.59E-05 | 0.006705 | 3.651105 | | NUPR1 | 1.018416 | 8.725291 | 10.60041 | 6.42E-06 | 0.004666 | 4.477638 | | S1PR3 | -1.00496 | 5.622551 | -7.97262 | 5.03E-05 | 0.011553 | 2.558468 | | HIST1H1A | -1.03222 | 5.249701 | -5.77463 | 0.000451 | 0.03452 | 0.381872 | | SCNN1A | -1.03907 | 7.479328 | -8.90881 | 2.28E-05 | 0.007694 | 3.314433 | | HIST1H2AB | -1.07344 | 8.065709 | -5.58109 | 0.000562 | 0.038202 | 0.158669 | | GLP2R | -1.11017 | 7.780635 | -11.02 | 4.82E-06 | 0.004101 | 4.731521 | | MYPN | -1.12719 | 7.42583 | -10.1703 | 8.70E-06 | 0.005247 | 4.203973 | | HIST1H2BI | -1.13604 | 6.08771 | -5.2416 | 0.000836 | 0.046549 | -0.24654 | | CCL2 | -1.14721 | 5.314616 | -12.6518 | 1.72E-06 | 0.002378 | 5.610076 | | S100A4 | -1.15053 | 6.164204 | -10.5789 | 6.51E-06 | 0.004688 | 4.464307 | | KIF20A | -1.15804 | 8.626588 | -11.5903 | 3.31E-06 | 0.003538 | 5.057388 | | HSPA1A | -1.18133 | 9.35104 | -11.0628 | 4.68E-06 | 0.004075 | 4.756747 | | ZNF831 | -1.18556 | 5.812955 | -6.95585 | 0.00013 | 0.01809 | 1.628511 | | HIST1H3A | -1.18869 | 6.441841 | -7.55158 | 7.37E-05 | 0.013674 | 2.1881 | | HSPA1B | -1.20391 | 9.316029 | -11.1242 | 4.49E-06 | 0.004075 | 4.792689 | | GATSL2 | -1.22061 | 7.183912 | -9.40487 | 1.54E-05 | 0.006705 | 3.680643 | | METTL7A | -1.241 | 6.802659 | -9.19234 | 1.82E-05 | 0.006822 | 3.526483 | | NPY4R | -1.3319 | 6.836449 | -8.96261 | 2.18E-05 | 0.007407 | 3.355245 | | LXN | -1.34896 | 6.031784 | -6.28611 | 0.000258 | 0.025948 | 0.945372 | | GATSL1 | -1.37709 | 7.131902 | -10.0593 | 9.43E-06 | 0.005498 | 4.131046 | | ALDH1A3 | -1.40489 | 7.11515 | -11.6537 | 3.18E-06 | 0.003504 | 5.092274 | | OLFML1 | -1.6252 | 7.527223 | -8.44414 | 3.35E-05 | 0.00908 | 2.950342 |
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