Research Article

Network Pharmacology and Bioinformatics Approach Reveals the Therapeutic Mechanism of Action of Baicalein in Hepatocellular Carcinoma

Table 3

Predicted targets of baicalein.

Protein nameGene symbol

Prostaglandin G/H synthase 1PTGS1
Androgen receptorAR
Prostaglandin G/H synthase 2PTGS2
Heat shock protein HSP 90HSP90AA1
Heat shock protein HSP 90HSP90AB1
mRNA of PKA Catalytic Subunit C-alphaPRKACA
Dipeptidyl peptidase IVDPP4
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoformPIK3CG
CGMP-inhibited 3′,5′-cyclic phosphodiesterase APDE3A
Trypsin-1PRSS1
Nuclear receptor coactivator 2NCOA2
Nuclear receptor coactivator 1NCOA1
CalmodulinCALM1
Transcription factor p65RELA
RAC-alpha serine/threonine-protein kinaseAKT1
Vascular endothelial growth factor AVEGFA
Apoptosis regulator Bcl-2BCL2
Proto-oncogene c-FosFOS
Apoptosis regulator BAXBAX
Matrix metalloproteinase-9MMP9
Caspase-3CASP3
Cellular tumor antigen p53TP53
Hypoxia-inducible factor 1-alphaHIF1A
Fos-related antigen 1FOSL1
Fos-related antigen 2FOSL2
Cell division control protein 2 homologCDK1
G2/mitotic-specific cyclin-B1CCNB1
MyeloperoxidaseMPO
Aryl hydrocarbon receptorAHR
Insulin-like growth factor IIIGF2
Cytochrome cCYCS
Arachidonate 12-lipoxygenase, 12S-typeALOX12
Nuclear factor of activated T-cells, cytoplasmic 1NFATC1
Tudor domain-containing protein 7TDRD7
Egl nine homolog 1EGLN1
NADPH oxidase 5NOX5
Fatty acid-binding protein, epidermalFABP5
Apolipoprotein DAPOD