Therapeutic Duration and Extent Affect the Effect of Moxibustion on Depression-Like Behaviour in Rats via Regulating the Brain Tryptophan Transport and Metabolism

<p><i>Metabolism pathways of Trp in human plasma and brain.</i> TRP: tryptophan, the precursor of kynurenine and serotonin; KYN: kynurenine; 5-HT: serotonin; TPH2: tryptophan hydroxylase, key enzyme of Trp-5-HT pathway; TDO: tryptophan 2,3-dioxygenase, key enzyme of Trp-Kyn pathway in liver; IDO: indoleamine 2,3- dioxygenase, key enzyme of Trp-Kyn pathway in tissues except liver; LAT1: large neutral amino acid transporter, transporter for Trp and Kyn on Blood-Brain-Barrier.</p>

Evidence-Based Complementary and Alternative Medicine

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Figure 1

Figure 1: Therapeutic Duration and Extent Affect the Effect of Moxibustion on Depression-Like Behaviour in Rats via Regulating the Brain Tryptophan Transport and Metabolism 

Figure 1 | Therapeutic Duration and Extent Affect the Effect of Moxibustion on Depression-Like Behaviour in Rats via Regulating the Brain Tryptophan Transport and Metabolism 