Acupuncture plus Chinese Herbal Medicine for Irritable Bowel Syndrome with Diarrhea: A Systematic Review and Meta-Analysis

Table 1

Characteristics of included literature.

Source	Criteria		Study population	Age (years)		N; (EG/CG)	Intervention		Outcomes	Follow-up	Side effects
	Western	TCM		EG	CG		EG	CG
Shi ZM; 2005	RomeII	N.M	Single center	20-55	22-58	30/30	Modified Sini Decoction and TXYF + Acupuncture	OT+DT+BT+MP	A	N.M	N.M
Hu FL; 2005	RomeII	N.M	Single center	22-68, mean:37	20-60, mean:35	37/32	Modified TXYF+ Acupuncture	CGEC+MP+OT	A	N.M	N.M
Zhang SY 2006	RomeII	LQSASDS	Single center	N.M	N.M	40/25	Oral: Modified Chaishao Yigong and Xiangsha Pingwei Decoction, Enema: Self-ordained TCM Decoction + Acupuncture	LHS+MP	A	N.M	N.M
Yu YG; 2007	RomeI	N.M	Single center	44	43	32/28	Chang Ling capsule + acupuncture	TDC	A	N.M	N.M
Lan YP; 2010	RomeII	LQSASDS	Single center	18-62	19-61	40/40	Modified TXYF+ Acupuncture	MP+OT	A+O	6 months	N.M
Cao S; 2011	RomeII	N.M	Single center	N.M	N.M	70/70	HXZQ Pill, or HXZQ Capsule, or HXZQ oral liquid; + Acupuncture	RP+MBND	A	N.M	N.M
Tang JL; 2011	Rome III	N.M	Two; centers	N.M	N.M	N.M	Jianpi Huazhuo Tongluo Decoction + Acupuncture	LBP	C+D+F+H+K+M+N+S	N.M	N.M
Jiang QY; 2013	Rome III	LSAASS	Single center	39.56±11.32	37.48±13.79	52/54	Chaihu Shugan Decoction + Acupuncture	OBT	A	N.M	T: 2 cases,; C: 1 case
Jin J; 2013	Rome III	N.M	Single center	42.52±3.73	42.94±3.81	52/52	Modified TXYF+ Acupuncture	RP, MBND	A+ T	N.M	T: 2 cases,; C: 3 cases
Zhou P; 2014	Rome III	LQSASDS	Single center	16~64,; mean:39.3	17~65,; mean:38.9	45/45	Modified XYS+ Acupuncture	MP+CGEC+CAECT	A+D+F+L+N+U	12 weeks	N.M
Yan YZ; 2014	Rome III	LQSASDS	Single center	38.25	36.75	52/50	Modified TXYF+ Acupuncture	PBT+CBLEABCT	A	N.M	C: 3 cases
Xu SC; 2015	Rome III	LQSASDS	Single center	42.3	40.9	30/30	Modified TXYF+ Acupuncture	PBT	A	N.M	N.M
Li YX; 2015	N.M	N.M	Single center	41.1±7.87	40.2±8.56	50/48	Modified XYS + Acupuncture	MP+CGEC	A+C+F+L+N	12 weeks	no
Sun W; 2015	Rome III	MBND	Single center	31.5±7.4	32.8±8.1	60/60	Jianpi Huazhuo Tongluo Decoction + Acupuncture	PBT	A	N.M	N.M
Zhi YC; 2016	Rome III	LQSASDS	Single center	42.4±7.4	41.8±7.3	30/30	Dunhuang Baoyuan Decoction + Acupuncture	PBT	A	N.M	C: 1case
Wang XH 2016	Rome III	CCSS	Single center	38.93±5.98	39.40±7.94	30/30	BXXX Decoction + Acupuncture	PBT	A+B	N.M	N.M
Chen S; 2016	Rome III	N.M	Single center	38.21±10.65	40.07±9.38	60/59	Shugan Jianpi Zhixie Decoction + Acupuncture	PBT	A+B	N.M	N.M
Yang JY; 2017	Rome III	N.M	Single center	48.20±4.59	47.49±5.23	35/35	Modified SLBZS+ Acupuncture	TMT	A+P+Q+R	4 weeks	C: 5cases
Hou GH; 2017	Rome III	LSAASS or WOSASS	Single center	36.75	37.55	52/52	CGECC+ Acupuncture	SB+PBT	A+C+D/E+F	N.M	C: 2 cases
Wang W; 2017	Rome III	DBLASS	Single center	35.2±4.3	36.2±5.0	102/105	Self-ordained TCM Decoction + Acupuncture	PBT	A+B+C+D+G+L+M	N.M	C: 3 cases
Sun M; 2017	Rome III	MBND	Single center	38.79±5.89	38.65±5.76	30/30	BXXX Decoction + Acupuncture	PBT	A+B	N.M	N.M

Annotation:
EG: experiment group; CG: control group; N.M: not mentioned; MBND: mentioned but not described;
CCS: cold-heat complicated syndrome; DBLASS: disharmony between liver and spleen syndrome; LQSASDS: Liver qi stagnation and spleen deficiency syndrome; LSAASS: Liver-qi stagnation and attacking spleen syndrome; WOSASS: weakness of spleen and stomach syndrome;
A: clinical therapeutic efficacy; B: TCM symptom therapeutic effect; C: abdominal pain score; D: abdominal distention score; E: abdominal discomfort score; F: diarrhea score; G: frequency of defecation score; H: mucous stool score; I: borborygmus score; J: property of stool score; K: tenesmus; L: diet condition score; M: sleeping quality score; N: physical strength; O: recurrence rate; P: IBS-QOL score; Q: IBS-BSS score; R: SCL 90; S: SF-36 scale; T: the level of serum inflammatory factor; U: the score of Hamilton Depression Rating Scale
BT: belladonna tablets; BXXX: Banxia Xiexin; CBLEABCT: combined bifidobacterium lactobacillus enterococcus and bacillus cereus tablets (Live); CGECC: compound glutamine enteric-coated capsules; DT: diazepam tablets; HXZQ: Huoxiang Zhengqi; LBP: live bifidobacterium preparation; LHS: loperamide hydrochloride capsules; MP: montmorillonite powder; OBT: otilonium bromide tablets; OT: oryzanol tablets; PBT: pinaverium bromide tablets; SB: saccharomyces boulardii sachets; SLBZS: Shenling Baizhu San; TMT: trimebutine maleate tablets; TXYF: Tongxie Yaofang; XYS: Xiayao San.