Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Tab 2

Research Article

Network Pharmacology-Based Investigation into the Mechanisms of Quyushengxin Formula for the Treatment of Ulcerative Colitis

Table 2

Details of 94 UC-related targets of herbs via UniProt.

IDUniProtProtein namesGene namesDegreeOrganism

1P35228Nitric oxide synthase, inducibleNOS225Homosapiens
2P23219Prostaglandin G/H synthase 1PTGS123Homosapiens
3P03372Estrogen receptorESR134Homosapiens
4P37231Peroxisome proliferator-activated receptor gammaPPARG21Homosapiens
5P35354Prostaglandin G/H synthase 2PTGS227Homosapiens
6Q92731Estrogen receptor betaESR217Homosapiens
7P11388DNA topoisomerase 2-alphaTOP2A5Homosapiens
8P16389Potassium voltage-gated channel subfamily H member 2KCNH213Homosapiens
9P08709Coagulation factor VIIF76Homosapiens
10P29474Nitric-oxide synthase, endothelialNOS321Homosapiens
11P27338Amine oxidase [flavin-containing] BMAOB5Homosapiens
12Q04206Transcription factor p65RELA6Homosapiens
13P00533Epidermal growth factor receptorEGFR1Homosapiens
14P31749RAC-alpha serine/threonine-protein kinaseAKT12Homosapiens
15P15692Vascular endothelial growth factor AVEGFA2Homosapiens
16P24385G1/S-specific cyclin-D1CCND13Homosapiens
17P10415Apoptosis regulator Bcl-2BCL25Homosapiens
18P01100Proto-oncogene c-FosFOS3Homosapiens
19P38936Cyclin-dependent kinase inhibitor 1CDKN1A4Homosapiens
20P55211Caspase-9CASP94Homosapiens
21P00749Urokinase-type plasminogen activatorPLAU4Homosapiens
22P0825372 kDa type IV collagenaseMMP22Homosapiens
23P14780Matrix metalloproteinase-9MMP92Homosapiens
24P22301Interleukin-10IL101Homosapiens
25P01133Proepidermal growth factorEGF1Homosapiens
26P06400Retinoblastoma-associated proteinRB12Homosapiens
27P01375Tumor necrosis factorTNF6Homosapiens
28P05412Transcription factor AP-1JUN4Homosapiens
29P05231Interleukin-6IL-63Homosapiens
30P42574Caspase-3CASP37Homosapiens
31P04637Cellular tumor antigen p53TP534Homosapiens
32P11926Ornithine decarboxylaseODC11Homosapiens
33Q14790Caspase-8CASP83Homosapiens
34P00441Superoxide dismutase [Cu-Zn]SOD12Homosapiens
35P17252Protein kinase C alpha typePRKCA2Homosapiens
36P03956Interstitial collagenaseMMP13Homosapiens
37P42224Signal transducer and activator of transcription 1-alpha/betaSTAT12Homosapiens
38P04626Receptor tyrosine-protein kinase erbB-2ERBB21Homosapiens
39P09601Heme oxygenase 1HMOX13Homosapiens
40P05177Cytochrome P450 1A2CYP1A22Homosapiens
41P01106Myc proto-oncogene proteinMYC1Homosapiens
42P05362Intercellular adhesion molecule 1ICAM14Homosapiens
43P01584Interleukin-1 betaIL1B5Homosapiens
44P13500C-C motif chemokine 2CCL21Homosapiens
45P19320Vascular cell adhesion protein 1VCAM12Homosapiens
46P10145Interleukin-8CXCL82Homosapiens
47P05771Protein kinase C beta typePRKCB2Homosapiens
48O15392Baculoviral IAP repeat-containing protein 5BIRC52Homosapiens
49P04792Heat shock protein beta-1HSPB11Homosapiens
50P01137Transforming growth factor beta-1TGFB13Homosapiens
51P60568Interleukin-2IL22Homosapiens
52Q16678Cytochrome P450 1B1CYP1B12Homosapiens
53P00750Tissue-type plasminogen activatorPLAT1Homosapiens
54P01579Interferon gammaIFNG4Homosapiens
55P09917Arachidonate 5-lipoxygenaseALOX53Homosapiens
56P60484Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN1Homosapiens
57P05164MyeloperoxidaseMPO1Homosapiens
58Q9UNQ0ATP-binding cassette subfamily G member 2ABCG21Homosapiens
59P09211Glutathione S-transferase PGSTP13Homosapiens
60Q16236Nuclear factor erythroid 2-related factor 2NFE2L21Homosapiens
61P15559NAD(P)H dehydrogenase [quinone] 1NQO12Homosapiens
62P09874Poly [ADP-ribose] polymerase 1PARP11Homosapiens
63P35869Aryl hydrocarbon receptorAHR2Homosapiens
64P19875C-X-C motif chemokine 2CXCL21Homosapiens
65O96017Serine/threonine-protein kinase Chk2CHEK21Homosapiens
66Q07869Peroxisome proliferator-activated receptor alphaPPARA1Homosapiens
67P02741C-reactive proteinCRP1Homosapiens
68P02778C-X-C motif chemokine 10CXCL101Homosapiens
69Q9NS23Ras association domain-containing protein 1RASSF11Homosapiens
70P17936Insulin-like growth factor-binding protein 3IGFBP31Homosapiens
71P01344Insulin-like growth factor IIIGF21Homosapiens
72P21860Receptor tyrosine-protein kinase erbB-3ERBB31Homosapiens
73P09488Glutathione S-transferase Mu 1GSTM12Homosapiens
74P282235-Hydroxytryptamine 2A receptorHTR2A4Homosapiens
75P84022Mothers against decapentaplegic homolog 3SMAD31Homosapiens
76P08588Beta-1 adrenergic receptorADRB13Homosapiens
77P29466Caspase-1CASP12Homosapiens
78P18509Pituitary adenylate cyclase-activating polypeptideADCYAP11Homosapiens
79O95456Proteasome assembly chaperone 1PSMG11Homosapiens
80P05112Interleukin-4IL-41Homosapiens
81P00325Alcohol dehydrogenase 1BADH1B1Homosapiens
82P28702Retinoic acid receptor RXR-betaRXRB1Homosapiens
83P04040CatalaseCAT1Homosapiens
84P01308InsulinINS1Homosapiens
85P21731Thromboxane A2 receptorTBXA2R1Homosapiens
86P07858Cathepsin BCTSB1Homosapiens
87P40763Signal transducer and activator of transcription 3STAT31Homosapiens
88Q00534Cell division protein kinase 6CDK61Homosapiens
89P09038Heparin-binding growth factor 2FGF21Homosapiens
90P15336Cyclic AMP-dependent transcription factor ATF-2ATF21Homosapiens
91P04141Granulocyte-macrophage colony-stimulating factorCSF21Homosapiens
92P17677NeuromodulinGAP431Homosapiens
93P18031Tyrosine-protein phosphatase nonreceptor type 1PTPN11Homosapiens
94P30279G1/S-specific cyclin-D2CCND21Homosapiens