The Combination of Mulberry Extracts and Silk Amino Acids Alleviated High Fat Diet-Induced Nonalcoholic Hepatic Steatosis by Improving Hepatic Insulin Signaling and Normalizing Gut Microbiome Dysbiosis in Rats
Figure 3
Relative gene expression related to fatty acid utilization and synthesis, oxidative stress, and inflammation, and hepatic insulin signaling. (a) Fold changes of mRNA expression of genes related to fatty acid synthesis. (b) Fold changes of mRNA expression of genes related to oxidative stress and inflammation. Each bar or dot and error bar represents the mean ± SD (n=10). Rats consumed high fat diets containing 0.2% (low dosage, -L) and 0.6% (high dosage, -H) of the mixture of mulberry extracts and silk amino acid (MS) and 0.6% cellulose (disease-control) for 12 weeks. MS1:3 and MS1:5 mixture contained 1:3 and 1:5 of mulberry extracts and silk amino acid, respectively. Bars with different letters were significantly different among the groups by Tukey test at P<0.05.