The Mechanism of MAPK Signal Transduction Pathway Involved with Electroacupuncture Treatment for Different Diseases
Table 1
List of electroacupuncture treatment-related diseases based on MAPK signal pathway.
Effect
MAPK signal pathway
Number of articles
Summary
Analgesia
p38MAPK, ERK
19
The mechanism of anti-inflammatory effects and amelioration of neuropathic pain is more complete, while that of the curative effect is specific. There are few reports on anti-delivery pain, and the specific mechanism needs to be further clarified.
Resisting injury accelerates injury repair
p38MAPK, ERK
3
Few studies have reported advantages in acute lung injury and post-traumatic immunosuppression.
Regulate gastrointestinal functions
ERK
3
Few studies have reported the advantages of gastric mucosa repair and maintenance of gastrointestinal functions.
Intervention in cardiovascular and cerebrovascular diseases
p38MAPK, ERK, JNK
19
It has effective regulatory effects on cerebral ischemia-reperfusion, Alzheimer's disease, cardiomyopathy, Parkinson's disease, and hypertension.
Other effects
p38MAPK
3
Few studies have reported the advantages of electroacupuncture in allergic dermatitis and knee diseases.