Herbal Formula Fo Shou San Attenuates Alzheimer’s Disease-Related Pathologies via the Gut-Liver-Brain Axis in APP/PS1 Mouse Model of Alzheimer’s Disease
Figure 1
FSS ameliorates cognitive dysfunction during behavioral testing in APP/PS1 AD mice. (a) Total swimming paths of the respective groups on the first and fifth day. (b) Escape latency for five consecutive daily tests (n = 8 per group). (c) Swimming average speed in the probe trial. (d) Number of times mice swam across the target platform in the probe trial. (e) Time spent in the target quadrant in the probe trial. (f) Percentage alternation in the Y maze test. (g) Preferential index in the novel object recognition test. Data represent the mean ± SEM (n = 6 per group). # P < 0.05, ## P < 0.01, and ### P < 0.001 compared with WT. P < 0.05, P < 0.01, and P < 0.001 compared with AD. FSS: Fo Shou San; AD: Alzheimer’s disease; WT: wild type; FSS-L: 1.6 g/kg/day; FSS-M: 3.2 g/kg/day; FSS-H: 6.4 g/kg/day.