Evaluation of Acute and Subacute Toxicities of Psidium guajava Methanolic Bark Extract: A Botanical with In Vitro Antiproliferative Potential

Table 2

Effect of oral administration of the Psidium guajava extract on the relative weight of organs and weight gain.

Parameters	Females				Males
	Control	250 mg/kg	500 mg/kg	1000 mg/kg	Control	250 mg/kg	500 mg/kg	1000 mg/kg
Liver	3.364 ± 0.077^c	2.928 ± 0.026^b	2.962 ± 0.037^b	2.842 ± 0.001^a	3.276 ± 0.133^c	2.770 ± 0.049^b	2.491 ± 0.002^a	2.694 ± 0.057^b
Kidney	0.573 ± 0.007^a	0.612 ± 0.001^b	0.610 ± 0.005^b	0.662 ± 0.0005^c	0.632 ± 0.015^a	0.633 ± 0.002^a	0.633 ± 0.001^a	0.630 ± 0.007^a
Heart	0.301 ± 0.004^a	0.362 ± 0.0006^c	0.355 ± 0.002^c	0.326 ± 0.007^b	0.324 ± 0.002^c	0.320 ± 0.006^c	0.271 ± 0.006^a	0.285 ± 0.002^b
Lung	0.534 ± 0.002^a	0.666 ± 0.005^b	0.710 ± 0.003^d	0.700 ± 0.005^c	0.725 ± 0.010^d	0.593 ± 0.022^b	0.546 ± 0.003^a	0.637 ± 0.0009^c
Spleen	0.472 ± 0.006^d	0.341 ± 0.007^a	0.370 ± 0.017^b	0.404 ± 0.005^c	0.509 ± 0.038^c	0.463 ± 0.006^b	0.397 ± 0.005^a	0.374 ± 0.001^a
Weight gain (g)	65.2	−2.9	1.5	−2.7	60.1	12.5	26.5	19.2

Data are expressed as mean ± standard deviation. n = 8 (4/sex); the values in the same line for a given sex followed by different letters in exponent are significantly different () according to the Newman–Keuls multiple comparison test.