Evidence-Based Complementary and Alternative Medicine

Research Article

Evaluation of Acute and Subacute Toxicities of Psidium guajava Methanolic Bark Extract: A Botanical with In Vitro Antiproliferative Potential

Table 3

Effect of oral administration of the Psidium guajava extract on hematological parameters.


Parameters	Females				Males
Parameters	Control	250 mg/kg	500 mg/kg	1000 mg/kg	Control	250 mg/kg	500 mg/kg	1000 mg/kg

WBC (10³/μL)	7.05 ± 1.17^a	9.16 ± 1.63^a	6.36 ± 1.38^a	10.05 ± 2.98^a	5.30 ± 2.21^a	6.40 ± 1.25^a	9.46 ± 0.93^a	7.95 ± 2.67^a
Lymphocytes (%)	41.58 ± 3.03^a	34.25 ± 5.85^a	36.23 ± 0.97^a	36.85 ± 2.52^a	34.40 ± 5.65^a	37.42 ± 3.27^a	36.17 ± 3.87^a	38.72 ± 1.53^a
Monocytes (%)	7.63 ± 1.92^a	7.76 ± 1.65^a	7.13 ± 0.30^a	11.30 ± 2.43^a	8.36 ± 1.57^a	6.36 ± 0.76^a	8.20 ± 3.47^a	9.23 ± 3.75^a
Granulocytes (%)	9.20 ± 4.18^a	23.73 ± 10.08^a	20.40 ± 2.21^a	15.00 ± 3.00^a	23.10 ± 9.80^a	18.80 ± 6.90^a	19.47 ± 4.32^a	13.33 ± 1.90^a
PLT (10³/μL)	677.3 ± 30.07^b	735.7 ± 16.50^b	751.0 ± 9.539^b	494.0 ± 76.08^a	396.0 ± 10.00^a	438.0 ± 47.84^a	529.7 ± 30.09^a	691.0 ± 108.5^b
MPV (fL)	11.83 ± 1.12^a	10.87 ± 1.79^a	10.93 ± 2.12^a	9.46 ± 0.75^a	9.83 ± 1.55^a	9.13 ± 0.37^a	8.80 ± 0.70^a	11.00 ± 1.40^a
RBC (10⁶/μL)	7.29 ± 0.20^a	7.32 ± 0.45^a	7.05 ± 0.09^a	8.08 ± 0.24^b	6.34 ± 1.93^a	8.07 ± 0.30^a	7.89 ± 0.52^a	7.67 ± 0.24^a
HGB (g/dL)	16.20 ± 0.10^a	16.40 ± 0.90^a	15.85 ± 0.05^a	16.10 ± 0.40^a	16.25 ± 0.05^a	17.07 ± 0.61^a	17.05 ± 0.15^a	17.00 ± 0.20^a
HCT (%)	43.50 ± 1.00^a	44.45 ± 2.45^a	41.50 ± 1.31^a	45.20 ± 2.10^a	43.25 ± 0.95^a	47.03 ± 0.80^a	45.53 ± 1.88^a	45.07 ± 4.53^a
MCV (fL)	62.60 ± 3.98^a	57.73 ± 2.80^a	58.93 ± 1.06^a	55.90 ± 3.89^a	58.00 ± 0.50^a	58.37 ± 1.41^a	60.15 ± 0.55^a	58.67 ± 4.10^a
MCH (pg)	22.70 ± 0.88^a	21.50 ± 0.50^a	21.87 ± 0.66^a	20.33 ± 1.42^a	21.75 ± 0.35^a	21.13 ± 1.29^a	21.20 ± 0.81^a	21.53 ± 0.80^a
MCHC (g/dL)	37.20 ± 1.10^a	37.40 ± 0.95^a	37.37 ± 0.66^a	36.43 ± 1.65^a	37.55 ± 0.95^a	36.27 ± 1.80^a	36.63 ± 1.01^a	36.90 ± 3.57^a

WBC: white blood cells; PLT: platelets; MPV: mean platelet volume; RBC: red blood cells; HGB: hemoglobin; HCT: hematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration. Data are expressed as mean ± standard deviation. n = 6 (3/sex); the values in the same line for a given sex followed by different letters in exponent are significantly different () according to the Newman–Keuls multiple comparison test.