Evaluation of Acute and Subacute Toxicities of Psidium guajava Methanolic Bark Extract: A Botanical with In Vitro Antiproliferative Potential
Table 3
Effect of oral administration of the Psidium guajava extract on hematological parameters.
Parameters
Females
Males
Control
250 mg/kg
500 mg/kg
1000 mg/kg
Control
250 mg/kg
500 mg/kg
1000 mg/kg
WBC (103/μL)
7.05 ± 1.17a
9.16 ± 1.63a
6.36 ± 1.38a
10.05 ± 2.98a
5.30 ± 2.21a
6.40 ± 1.25a
9.46 ± 0.93a
7.95 ± 2.67a
Lymphocytes (%)
41.58 ± 3.03a
34.25 ± 5.85a
36.23 ± 0.97a
36.85 ± 2.52a
34.40 ± 5.65a
37.42 ± 3.27a
36.17 ± 3.87a
38.72 ± 1.53a
Monocytes (%)
7.63 ± 1.92a
7.76 ± 1.65a
7.13 ± 0.30a
11.30 ± 2.43a
8.36 ± 1.57a
6.36 ± 0.76a
8.20 ± 3.47a
9.23 ± 3.75a
Granulocytes (%)
9.20 ± 4.18a
23.73 ± 10.08a
20.40 ± 2.21a
15.00 ± 3.00a
23.10 ± 9.80a
18.80 ± 6.90a
19.47 ± 4.32a
13.33 ± 1.90a
PLT (103/μL)
677.3 ± 30.07b
735.7 ± 16.50b
751.0 ± 9.539b
494.0 ± 76.08a
396.0 ± 10.00a
438.0 ± 47.84a
529.7 ± 30.09a
691.0 ± 108.5b
MPV (fL)
11.83 ± 1.12a
10.87 ± 1.79a
10.93 ± 2.12a
9.46 ± 0.75a
9.83 ± 1.55a
9.13 ± 0.37a
8.80 ± 0.70a
11.00 ± 1.40a
RBC (106/μL)
7.29 ± 0.20a
7.32 ± 0.45a
7.05 ± 0.09a
8.08 ± 0.24b
6.34 ± 1.93a
8.07 ± 0.30a
7.89 ± 0.52a
7.67 ± 0.24a
HGB (g/dL)
16.20 ± 0.10a
16.40 ± 0.90a
15.85 ± 0.05a
16.10 ± 0.40a
16.25 ± 0.05a
17.07 ± 0.61a
17.05 ± 0.15a
17.00 ± 0.20a
HCT (%)
43.50 ± 1.00a
44.45 ± 2.45a
41.50 ± 1.31a
45.20 ± 2.10a
43.25 ± 0.95a
47.03 ± 0.80a
45.53 ± 1.88a
45.07 ± 4.53a
MCV (fL)
62.60 ± 3.98a
57.73 ± 2.80a
58.93 ± 1.06a
55.90 ± 3.89a
58.00 ± 0.50a
58.37 ± 1.41a
60.15 ± 0.55a
58.67 ± 4.10a
MCH (pg)
22.70 ± 0.88a
21.50 ± 0.50a
21.87 ± 0.66a
20.33 ± 1.42a
21.75 ± 0.35a
21.13 ± 1.29a
21.20 ± 0.81a
21.53 ± 0.80a
MCHC (g/dL)
37.20 ± 1.10a
37.40 ± 0.95a
37.37 ± 0.66a
36.43 ± 1.65a
37.55 ± 0.95a
36.27 ± 1.80a
36.63 ± 1.01a
36.90 ± 3.57a
WBC: white blood cells; PLT: platelets; MPV: mean platelet volume; RBC: red blood cells; HGB: hemoglobin; HCT: hematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration. Data are expressed as mean ± standard deviation. n = 6 (3/sex); the values in the same line for a given sex followed by different letters in exponent are significantly different () according to the Newman–Keuls multiple comparison test.