Evaluation of Acute and Subacute Toxicities of Psidium guajava Methanolic Bark Extract: A Botanical with In Vitro Antiproliferative Potential

Table 4

Effect of oral administration of the Psidium guajava extract on urinary biochemical parameters.

Parameters	Females				Males
	Control	250 mg/kg	500 mg/kg	1000 mg/kg	Control	250 mg/kg	500 mg/kg	1000 mg/kg
Creatinine (mg/dL)	53.07 ± 0.832^c	42.00 ± 0.400^a	38.80 ± 3.555^a	48.53 ± 1.007^b	64.13 ± 3.449^a	63.87 ± 1.890^a	63.87 ± 2.663^a	58.40 ± 6.053^a
Urea (mg/dL)	1921 ± 184.2^ab	1618 ± 197.4^a	1877 ± 84.59^ab	2066 ± 118.4^b	1579 ± 105.3^a	1482 ± 99.63^a	4355 ± 171.1^c	2649 ± 30.39^b
Proteins (g/dL)	0.2721 ± 0.042^a	0.1837 ± 0.020^a	0.7211 ± 0.135^b	1.020 ± 0.040^c	1.136 ± 0.112^a	1.252 ± 0.023^ab	1.306 ± 0.035^b	1.395 ± 0.042^b

Data are expressed as mean ± standard deviation. n = 8 (4/sex); the values in the same line for a given sex followed by different letters in exponent are significantly different () according to the Newman–Keuls multiple comparison test.