Evaluation of Acute and Subacute Toxicities of Psidium guajava Methanolic Bark Extract: A Botanical with In Vitro Antiproliferative Potential

Table 5

Effect of oral administration of the Psidium guajava extract on serum biochemical parameters.

Parameters	Females				Males
	Control	250 mg/kg	500 mg/kg	1000 mg/kg	Control	250 mg/kg	500 mg/kg	1000 mg/kg
ALT (U/I)	66.20 ± 1.968^a	64.75 ± 2.404^a	70.36 ± 5.099^a	68.33 ± 1.758^a	89.57 ± 2.362^c	74.21 ± 3.148^b	42.49 ± 5.613^a	41.47 ± 3.573^a
AST (U/I)	46.27 ± 2.310^a	71.88 ± 1.817^c	64.02 ± 2.667^b	58.46 ± 5.535^b	79.44 ± 0.873^c	66.06 ± 2.197^a	69.84 ± 1.155^b	65.85 ± 1.671^a
Total cholesterol (mg/dL)	47.14 ± 2.277^a	62.99 ± 2.364^c	61.27 ± 0.735^c	52.70 ± 1.767^b	90.69 ± 2.414^d	64.79 ± 4.614^b	53.19 ± 1.068^a	70.51 ± 1.258^c
HDL cholesterol (mg/dL)	35.72 ± 0.705^b	34.88 ± 5.009^b	26.57 ± 1.301^a	21.04 ± 3.239^a	31.74 ± 2.260^a	42.24 ± 4.495^b	49.80 ± 4.061^c	56.92 ± 1.596^d
LDL cholesterol (mg/dL)	22.25 ± 2.873^a	38.32 ± 7.160^b	44.58 ± 0.7714^b	40.99 ± 4.274^b	69.70 ± 0.777^d	32.84 ± 6.584^c	14.16 ± 4.669^a	24.42 ± 0.809^b
Triglycerides (mg/dL)	54.14 ± 0.885^c	51.02 ± 1.113^b	49.37 ± 0.692^b	46.71 ± 1.113^a	53.77 ± 0.692^a	51.48 ± 1.262^a	53.87 ± 1.301^a	54.14 ± 1.113^a
Creatinine (mg/dL)	1.036 ± 0.045^c	0.571 ± 0.054^b	0.631 ± 0.045^b	0.488 ± 0.023^a	0.4762 ± 0.038^a	0.7738 ± 0.045^b	0.8929 ± 0.071^c	1.048 ± 0.086^d
Urea (mg/dL)	69.91 ± 4.243^a	82.41 ± 6.263^b	90.28 ± 1.389^b	84.26 ± 1.604^b	70.83 ± 1.389^a	74.07 ± 5.782^a	78.70 ± 2.122^a	89.81 ± 5.613^b
Total proteins (g/dL)	4.926 ± 0.071^c	4.192 ± 0.112^b	4.072 ± 0.124^b	3.501 ± 0.023^a	3.426 ± 0.141^b	3.401 ± 0.117^b	3.015 ± 0.069^a	2.878 ± 0.118^a

ALT: alanine aminotransferase; AST: aspartate aminotransferase. Data are expressed as mean ± standard deviation. n = 8 (4/sex); the values in the same line for a given sex followed by different letters in exponent are significantly different () according to the Newman–Keuls multiple comparison test.