Antimalarial Activity of Cordia africana (Lam.) (Boraginaceae) Leaf Extracts and Solvent Fractions in Plasmodium berghei-Infected Mice

Table 1

Effect of crude extracts on parasitemia level, suppression, and mean survival time in the four-day suppression test.

Group	Doses (mg/kg)	% parasitaemia (mean ± SEM)	% suppression	Mean survival time (days)
dH2O	10 ml/kg	45.97 ± 0.56	0.00	6.33 ± 0.33
CQ	25	0 ± 0.00^a3	100^a3	30.00 ± 0.00^a3
CA	200	37.51 ± 0.39^a3,b3,d3,e3	18.41^a3,b3,d3,e3	7.17 ± 0.31^b3,e3
CA	400	25.67 ± 0.48^a3,b3,c3	44.16^a3,b3,c3,e3	8.50 ± 0.22^a3,b3
CA	600	22.44 ± 1.16^a3,b3,c3	51.19^a3,b3,c3,d3	9.67 ± 0.42^a3,b3,c3

Data are expressed as mean ± SEM; n = 6; a, compared to 10 ml/kg dH₂O (negative control); b, compared to CQ 25 mg/kg; c, compared to 200 mg/kg of the extract; d, compared to 400 mg/kg of the extract; e, compared to 600 mg/kg of the extract; ¹; ²; ³; CQ, chloroquine; CA, 80% methanol crude leaf extract of Cordia africana; dH₂O, distilled water. Numbers refer to dose in mg/kg/day.