Antimalarial Activity of Cordia africana (Lam.) (Boraginaceae) Leaf Extracts and Solvent Fractions in Plasmodium berghei-Infected Mice

Table 3

% of parasitemia, suppression, and survival time of crude extracts in Rane’s test.

Group	Doses (mg/kg)	D3	D4	D5	D6	D7	% suppression	Mean survival time (day)
dH2O	10 ml/kg	10.39 ± 0.95	23.06 ± 2.58	27.93 ± 2.59	35.13 ± 0.46	44.37 ± 1.75	0.00	6.67 ± 0.21
CQ	25	11.67 ± 0.65	7.09 ± 0.49	1.82 ± 0.29	0.00 ± 0.00	0.00 ± 0.00^a3	100.00	30.00 ± 0.00^a3
CA	200	9.42 ± 0.63	20.93 ± 1.62	22.58 ± 1.31	24.69 ± 0.78	29.93 ± 1.38^a3,b3,e3	32.56	8.33 ± 0.33^b3,e3
CA	400	12.08 ± 0.57	21.34 ± 0.88	20.42 ± 0.90	21.73 ± 0.50	24.02 ± 1.99^a3,b3	45.86	9.83 ± 0.40^a3,b3
CA	600	13.78 ± 0.78	18.29 ± 1.06	19.24 ± 1.94	18.72 ± 1.11	19.02 ± 0.48^a3,b3,c3	57.14	10.50 ± 0.43^a3,b3,c3

Data are expressed as mean ± SEM; n = 6; a, compared to 10 ml/kg dH₂O (negative control); b, compared to CQ 25 mg/kg (positive control); c, compared to 200 mg/kg of the extract; d, compared to 400 mg/kg of the extract; e, compared to 600 mg/kg of the extract; ¹; ²; ³; CQ, chloroquine; CA, 80% methanol crude leaf extract of Cordia africana; dH₂O, distilled water. Numbers refer to dose in mg/kg/day.