Antimalarial Activity of Cordia africana (Lam.) (Boraginaceae) Leaf Extracts and Solvent Fractions in Plasmodium berghei-Infected Mice

Table 4

Body weight of mice treated with crude extracts in Rane’s test.

Group	Doses (mg/kg)	Body weight (gram)		% change
		D3	D7
dH2O	10 ml/kg	28.28 ± 1.16	25.51 ± 0.93	−9.77
CQ	25	28.18 ± 0.77	28.54 ± 0.76	1.25^a3
CA	200	33.13 ± 0.88	31.36 ± 0.93	−5.37^a3,b3,e1
CA	400	33.16 ± 0.45	32.54 ± 0.43	−1.86^a3,b2
CA	600	31.28 ± 1.21	30.94 ± 1.27	−1.09^a3,c1

Data are expressed as mean ± SEM; n = 6; a, compared to 10 ml/kg dH₂O (negative control); b, compared to CQ 25 mg/kg (positive control); c, compared to 200 mg/kg of the extract; d, compared to 400 mg/kg of the extract; e, compared to 600 mg/kg of the extract; ¹; ²; ³; D3, pretreatment value on day 3 after infection; D7, posttreatment value on day 7; CQ, chloroquine; CA, 80% methanol crude leaf extract of Cordia africana; dH₂O, distilled water. Numbers refer to dose in mg/kg/day.