Antimalarial Activity of Cordia africana (Lam.) (Boraginaceae) Leaf Extracts and Solvent Fractions in Plasmodium berghei-Infected Mice

Table 5

Effect of crude extracts on % parasitemia level, suppression, and survival time in prophylactic test.

Group	Doses (mg/kg)	% parasitaemia (M ± SEM)	% suppression	Mean survival time (days)
dH2O	10 ml/kg	43.87 ± 0.90	0.00	6.50 ± 0.22
CQ	25	0.86 ± 0.43^a3	98.03	30 ± 0.00^a3
CA	200	33.68 ± 0.71^a3,b3,d3,e3	23.22	7.33 ± 0.33^b3,d1,e3
CA	400	25.87 ± 0.40^a3,b3,c3	41.02	8.83 ± 0.31^a3,b3,c1
CA	600	23.48 ± 0.62^a3,b3,c3	46.48	9.17 ± 0.31^a3,b3,c3

Data are expressed as mean ± SEM; n = 6; a, compared to 10 ml/kg dH₂O (negative control); b, compared to CQ 25 mg/kg (positive control); c, compared to 200 mg/kg of the extract; d, compared to 400 mg/kg of the extract; e, compared to 600 mg/kg of the extract; ¹; ²; ³; CQ, chloroquine; CA, 80% methanol crude leaf extract of Cordia africana. Numbers refer to dose in mg/kg/day.