Antimalarial Activity of Cordia africana (Lam.) (Boraginaceae) Leaf Extracts and Solvent Fractions in Plasmodium berghei-Infected Mice

Table 6

Effect of crude extracts on rectal temperature and body weight of mice before and after inoculation in prophylactic test.

Group	Doses (mg/kg)	Weight (gram)		% change	Temperature (°C)		% change
		D0	D3		D0	D3
dH2O	10 ml/kg	31.98 ± 1.09	29.37 ± 0.94	−8.16	36.62 ± 0.10	33.82 ± 0.34	−7.65
CQ	25	32.04 ± 1.14	31.75 ± 1.10	−0.60^a3	37.12 ± 0.20	36.70 ± 0.07	−1.12^a3
CA	200	31.57 ± 0.96	30.07 ± 0.96	−4.77^b2	36.89 ± 0.13	35.25 ± 0.28	−4.45
CA	400	29.73 ± 0.99	28.87 ± 0.97	−3.43^a3	37.23 ± 0.15	35.77 ± 0.16	−3.93
CA	600	30.79 ± 0.97	30.22 ± 1.00	−1.84^a3	37.60 ± 0.18	36.85 ± 0.15	−1.99^a3

Data are expressed as mean ± SEM; n = 6; a, compared to 10 ml/kg dH₂O (negative control); b, compared to CQ 25 mg/kg (positive control); c, compared to 200 mg/kg of the extract; d, compared to 400 mg/kg of the extract; e, compared to 600 mg/kg of the extract; ¹; ²; ³; CQ, chloroquine; CA, 80% methanol crude leaf extract of Cordia africana; D0, pretreatment value on day 0; D3, posttreatment value on day 3. Numbers refer to dose in mg/kg/.