Antimalarial Activity of Cordia africana (Lam.) (Boraginaceae) Leaf Extracts and Solvent Fractions in Plasmodium berghei-Infected Mice

Table 7

% of parasitemia, suppression, and survival time solvent fractions in four-day suppression test.

Group	Doses (mg/kg)	% parasitaemia (mean ± SEM)	% suppression	Mean survival time (days)
2% DMSO	10 ml/kg	52.69 ± 2.13	0.00	6.50 ± 0.22
CQ	25	0.00 ± 0.00^a3	100	30.00 ± 0.00^a3
AF	100	44.08 ± 1.72^a1,b3	16.34	7.33 ± 0.33^b3
AF	200	40.82 ± 0.80^a3,b3	22.53	8.00 ± 0.26^a1,b3
AF	400	37.64 ± 1.28^a3,b3	28.56	8.17 ± 0.31^a2,b3
BF	100	36.51 ± 2.04^a3,b3,d1,e3	30.71	7.67 ± 0.21^b3,e3
BF	200	27.28 ± 1.20^a3,b3,c1	48.22	9.00 ± 0.37^a3,b3
BF	400	23.39 ± 1.48^a3,b3,c3	55.62	10.33 ± 0.42^a3,b3,c3
CF	100	43.49 ± 0.85^b3,d2,e3	17.45	7.50 ± 0.22^b3,e3
CF	200	31.70 ± 1.95^a3,b3,c2	39.84	8.33 ± 0.21^a3,b3
CF	400	28.96 ± 2.49^a3,b3,c3	45.04	9.67 ± 0.42^a3,b3,c3

Data are expressed as mean ± SEM; n = 6; a, compared to 10 ml/kg 2% DMSO (negative control); b, compared to CQ 25 mg/kg (positive control); c, compared to 100 mg/kg of the fraction; d, compared to 200 mg/kg of the fraction; e, compared to 400 mg/kg of the fraction; ¹; ²; ³; AF, aqueous fraction; BF, n-butanol fraction; CF, chloroform fraction; CQ, chloroquine; DMSO, dimethyl sulfoxide.