Antimalarial Activity of Cordia africana (Lam.) (Boraginaceae) Leaf Extracts and Solvent Fractions in Plasmodium berghei-Infected Mice

Table 8

Body weight of P. berghei-infected mice treated with solvent fractions in four-day suppression test.

Group	Doses (mg/kg)	Body weight (gram)		% change
		D0	D4
2% DMSO	10 ml/kg	32.62 ± 1.46	29.25 ± 1.30	−10.32
CQ	25	26.73 ± 1.62	27.27 ± 1.53	2.02^a3
AF	100	32.33 ± 1.02	29.21 ± 1.10	−9.67^b3
AF	200	32.84 ± 2.09	30.70 ± 1.97	−6.53^b3
AF	400	33.32 ± 1.45	31.62 ± 1.71	−5.10^b2
BF	100	30.68 ± 0.89	29.88 ± 0.86	−2.62^a3,b1
BF	200	26.73 ± 1.62	26.61 ± 1.67	−0.42^a3
BF	400	34.20 ± 0.83	34.47 ± 0.76	0.79^a3
CF	100	28.82 ± 0.97	26.68 ± 0.87	−7.43^b3,e1
CF	200	30.04 ± 1.05	29.02 ± 1.02	−3.38^a3,b1
CF	400	32.20 ± 1.00	31.50 ± 1.05	−2.16^a3,c1

Data are expressed as mean ± SEM; n = 6; a, compared to 10 ml/kg 2% DMSO (negative control); b, compared to CQ 25 mg/kg (positive control); c, compared to 100 mg/kg of the fraction; d, compared to 200 mg/kg of the fraction; e, compared to 400 mg/kg of the fraction; ¹; ²; ³; AF, aqueous fraction; BF, n-butanol fraction; CF, chloroform fraction; CQ, chloroquine; D0, pretreatment value on day 0; D4, posttreatment value on day 4; DMSO, dimethyl sulfoxide.