Effects of Xuesaitong on the Pharmacokinetics of Losartan: An In Vivo UPLC-MS/MS Study

Table 3

Stability outcomes of losartan and EXP3174 in rat plasma (n = 5).

Compounds	Concentration (ng·mL^−1)	Storage at 25°C for 3 h		Storage at 4°C for 24 h		Three freeze-thaw cycles		Long-term storage at −80°C for 30 days
		Measured (ng·mL^−1)	RE (%)	Measured (ng·mL^−1)	RE (%)	Measured (ng·mL^−1)	RE (%)	Measured (ng·mL^−1)	RE (%)
Losartan	5	5.25	5.00	5.47	8.30	5.39	6.71	5.41	8.31
	100	104.60	4.60	109.52	9.52	106.54	6.54	107.46	7.46
	1600	1633.48	2.09	1673.44	4.59	1576.38	−1.48	1686.27	5.39
EXP3174	5	5.37	7.40	5.49	7.76	5.44	7.78	5.46	7.15
	100	102.33	2.33	107.57	7.57	97.22	−2.78	94.40	−5.60
	1600	1648.96	3.06	1653.63	3.35	1487.01	−7.06	1492.90	−6.94

RSD, relative standard deviation; RE, relative error.