Evidence-Based Complementary and Alternative Medicine / 2019 / Article / Fig 4

Research Article

C-Phycocyanin Alleviates Bladder Inflammation and Dysfunction in Cyclophosphamide-Induced Cystitis in a Mouse Model by Inhibiting COX-2 and EP4

Figure 4

The expressions of COX-2 and EP4 in bladder. (a) The locations of COX-2 (green) and EP4 (red) in the bladder. The control group exhibited weak COX-2 -IR and EP4 -IR signals in the mucosa and detrusor, respectively. The CYP group exhibited stronger COX-2 -IR and EP4 -IR in the same location, and pretreatment with C-PC also resulted in the visible intensity of COX-2 -IR and EP4 -IR. Yellow dotted lines delineated the boundary of urothelium. Scale bar 25 μm. (b) mRNA relative expression. Transcription levels of Cox-2 and Ep4 increased significantly after CYP treatment, and C-PC reduced the expressions of those genes. p <0.05, p<0.01.


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