Cytotoxicity of Crude Extract and Isolated Constituents of the Dichrostachys cinerea Bark towards Multifactorial Drug-Resistant Cancer Cells

Figure 6

ROS production in CCRF-CEM cells treated for 24 h with the crude extract, betulinic acid (1), and hydrogen peroxide (H₂O₂). Samples were tested at their 1/4 × IC₅₀, 1/2 × IC₅₀, IC₅₀, and 2 × IC₅₀; IC₅₀ values were 5.69 μg/mL for the crude extract and 8.80 μM for 1. Shown are mean±SD of three independent experiments.