Safety and Clinical Efficacy of Yangxue Qingnao Granules in the Treatment of Chronic Cerebral Circulation Insufficiency: A Systematic Review and Meta-Analysis

Table 2

GRADE summary of five randomized controlled trials comparing YXQN granules plus routine treatment with nimodipine tablets plus routine treatment in chronic cerebellar circulation insufficiency.

Outcomes	Anticipated absolute effects (95% CI)		Relative effect (95% CI)	No. of participants (studies)	Certainty of the evidence (GRADE)
	Assumed risk: nimodipine tablets plus routine treatment	Corresponding risk: YXQN granules plus routine treatment
BA blood flow velocity	The mean BA blood flow velocity in the control groups was 45.37	The mean BA blood flow velocity in the intervention groups was 3.34-fold higher (2.31- to 4.37-fold higher)	—	272 (3 RCTs)
VA blood flow velocity	The mean VA blood flow velocity in the control groups was 40.55	The mean VA blood flow velocity in the intervention groups was 3.21-fold higher (0.62- to 5.8-fold higher)	—	352 (4 RCTs)
ICA blood flow velocity	The mean ICA blood flow velocity in the control groups was 50.7	The mean ICA blood flow velocity in the intervention groups was 7.46-fold higher (2.01- to 12.9-fold higher)	—	189 (2 RCTs)
Clinical efficacy of TCM symptoms	642 per 1000	883 per 1,000 (817–927)	RR 4.21 (2.49 to 7.12)	386 (5 RCTs)

The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RR: risk ratio. GRADE Working Group grades of evidence: high certainty: we are very confident that the true effect lies close to that of the estimate of the effect; moderate certainty: we are moderately confident in the effect estimate. The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different; low certainty: our confidence in the effect estimate is limited. The true effect may be substantially different from the estimate of the effect; and very low certainty: we have very little confidence in the effect estimate. The true effect is likely to be substantially different from the estimate of the effect. ^aAccording to the risk-of-bias graph. ^bTotal number of events was less than 300.