Research Article

Effect of Xylocarpus granatum Bark Extract on Amelioration of Hyperglycaemia and Oxidative Stress Associated Complications in STZ-Induced Diabetic Mice

Table 6

Effect of X. granatum on antioxidant enzymes in liver and brain tissues. Data are expressed as mean ± S.D., n=5. NC, Control mice; NCT, Normal Control mice +Toxicological (high) dose Xylocarpus granatum; DMC, Diabetic Control mice; DMD, Diabetic mice+ Drug (Glibenclamide); DML, Diabetic mice + Xylocarpus granatum Low dose (100 mg/kg); DMH, Diabetic mice + Xylocarpus granatum High dose (200 mg/kg). p< 0.05 compared with the control mice (NC); p< 0.05 compared with the diabetic control mice (DMC).

OrgansGroupSODCATGPxGRGST
(U/mg)(nKatal/mg)(nmoles/min/mg protein)(nmoles/min/mg protein)(nmoles/min/mg protein)

LiverNC15.77 ± 2.803418.06 ± 375.1926.11 ± 2.2920.09 ± 4.922949.81 ± 116.54
NCT17.59 ± 4.202960.5 ± 761.7130.62 ± 2.8020.69 ± 2.072416.51 ± 314.9
DMC8.10 ± 0.403297.6 ± 591.1533.05 ± 1.3112.55 ± 1.482083.95 ± 336.6
DMD14.72 ± 1.423792.69 ± 489.0826.81 ± 0.8224.0 ± 1.842093.61 ± 310.56
DML18.58 ± 4.133892.74 ± 216.7522.02 ± 2.7121.05 ± 2.232416.51 ± 630.83
DMH18.35 ± 2.724344.26 ± 779.3825.39 ± 1.1125.39 ± 3.282016.54 ± 407.26
BrainNC12.87 ± 2.7145.87 ± 13.4426.42 ± 1.198.48 ± 0.43261.64 ± 9.94
NCT12.02 ± 1.2347.31 ± 11.0130.22 ± 0.399.8 ± 1.17306.22 ± 10.82
DMC10.08 ± 0.3955.91 ± 7.4433.19 ± 2.626.32 ± 0.57222.89 ± 4.65
DMD11.32 ± 2.437.27 ± 2.8618.08 ± 1.4811.81 ± 1.49270.81 ± 10.62
DML10.56 ± 1.1145.87 ± 9.9323.27 ± 2.067.32 ± 0.69226.21 ± 6.84
DMH10.65 ± 1.9241.57 ± 6.2426.58 ± 1.148.93 ± 0.69299.14 ± 8.0