Efficiency of Sophora flavescens-Fructus Ligustri Lucidi Drug Pairs in the Treatment of Liver Fibrosis Based on the Response Surface Method
Table 1
Effect of Sophora flavescens-Fructus Ligustrum lucidum drug pair treatment on blood and liver indexes in mice with liver fibrosis (x±s, n=8), for different drug ratios (1:0, 0:1, 1:1, 1:2, 1:3, 2:1, and 3:1) and dosages (low (L), medium (M), and high (H)).
Group
ALT
AST
SOD
MDA
ALP
HI
Normal
24.81±1.90
94.38±5.46
322.40±9.29
8.03±0.14
64.96±3.36
3.39±0.17
Model
118.62±5.90##
318.28±4.33##
160.47±2.79##
24.47±0.89##
191.61±3.71##
9.77±0.01##
Positive control
38.71±2.14
128.38±6.25
299.41±7.05
9.11±0.45
72.39±3.93
3.81±0.7
1:0 (L)
116.52±7.30
312.39±2.84
163.15±4.19
23.49±0.87
189.52±2.50
9.31±0.92
1:0 (M)
113.82±5.54
309.32±10.37
172.07±1.14
22.55±1.48
187.38±4.28
9.19±1.00
1:0 (H)
110.40±6.36
304.13±8.63
176.23±6.97
22.34±1.31
181.56±9.33
9.09±0.37
0:1 (L)
115.75±3.71
307.14±9.84
180.22±4.15
23.20±0.80
189.94±1.31
9.09±0.72
0:1 (M)
113.34±5.27
301.29±8.96
185.80±10.32
23.05±1.21
185.40±5.09
8.51±0.57
0:1 (H)
111.92±7.45
300.04±5.25
188.18±6.41
21.00±0.39
181.07±4.24
8.69±0.84
1:1 (L)
105.33±3.83
224.43±7.15
231.12±4.24
17.06±0.94
140.19±5.09
6.69±0.53
1:1(M)
94.53±7.00
183.29±6.71
240.52±6.67
15.32±1.27
128.92±3.65
6.15±0.86
1:1 (H)
101.81±11.72
171.04±6.19
233.28±7.29
14.3±1.01
121.63±3.28
6.23±0.877
1:2 (L)
77.71±5.66
152.46±7.17
273.17±5.96
12.84±0.74
98.46±3.86
4.59±0.108
1:2 (M)
70.46±3.63
134.35±2.65
280.28±4.41
10.15±2.74
81.31±2.96
4.19±0.46
1:2 (H)
64.54±5.33
127.88±3.88
289.46±4.10
9.66±0.88
79.33±4.21
4.46±0.05
1:3 (L)
87.33±4.84
298.51±5.16
248.53±3.33
13.11±1.12
108.48±4.26
5.71±0.52
1:3(M)
84.27±6.00
290.53±12.22
260.45±9.08
14.01±1.52
113.24±5.32
5.36±0.51
1:3 (H)
82.56±3.77
291.87±7.7
270.52±7.93
12.88±0.13
101.14±3.38
5.27±0.14
2:1 (L)
105.59±7.78
272.17±11.48
214.52±6.00
18.45±0.54
160.97±4.26
6.44±0.08
2:1 (M)
104.54±6.91
270.52±8.42
213.03±4.53
18.75±0.26
157.42±3.81
6.63±0.60
2:1(H)
106.36±8.84
270.39±3.93
210.72±3.63
18.05±0.81
153.43±2.25
6.76±0.37
3:1 (L)
110.72±7.75
298.514±6.01
189.45±2.9
20.55±0.40
182.66±2.23
8.36±0.65
3:1 (M)
108.83±4.06
290.53±7.00
192.82±2.64
20.11±1.24
174.53±4.95
8.15±0.435
3:1 (H)
109.44±6.69
291.81±3.87
197.12±2.89
20.18±1.17
162.39±4.14
7.77±0.90
P < 0.01 versus normal group; P < 0.05 P < 0.01 versus model group.
