Acute and Subchronic Oral Toxicity of Fermented Green Tea with Aquilariae Lignum in Rodents
Table 5
Serum biochemical changes after a repeated oral dose of fGT for 13 weeks.
Control (male/female)
fGT (male/female)
2.0 g/kg
1.0 g/kg
0.5 g/kg
ALP (IU/dL)
32.42 ± 13.85/20.18 ± 7.41
28.90 ± 6.16/22.02 ± 8.27
31.62 ± 11.75/21.84 ± 9.09
28.40 ± 4.37/18.34 ± 6.36
AST (IU/dL)
12.48 ± 4.10/10.70 ± 2.54
10.86 ± 2.01/9.86 ± 0.73
10.84 ± 1.25/10.74 ± 3.59
12.38 ± 2.62/9.04 ± 1.10
ALT (IU/L)
32.80 ± 8.17/27.80 ± 5.50
27.60 ± 4.72/24.40 ± 4.10
25.40 ± 3.21/36.00 ± 29.07
26.40 ± 4.45/25.80 ± 8.73
LDH (IU/dL)
90.00 ± 0.00/86.94 ± 6.84
90.00 ± 0.00/90.00 ± 0.00
86.60 ± 7.60/88.58 ± 3.18
90.00 ± 0.00/87.32 ± 5.99
BUN (mg/dL)
14.60 ± 1.47/13.50 ± 2.38
14.54 ± 2.03/14.88 ± 3.15
13.82 ± 1.76/13.78 ± 1.11
13.80 ± 0.82/14.90 ± 2.39
Glucose (mg/dL)
142.80 ± 27.94/137.00 ± 23.00
148.20 ± 22.58/128.20 ± 21.23
155.00 ± 10.32/145.80 ± 26.83
126.60 ± 13.79/133.20 ± 26.29
Total cholesterol (mg/dL)
67.80 ± 12.72/85.60 ± 12.26
66.60 ± 16.67/80.20 ± 12.26
61.00 ± 6.56/80.66 ± 42.10
57.20 ± 7.19/77.60 ± 15.42
Triglyceride (mg/dL)
80.20 ± 21.83/76.60 ± 10.14
110.20 ± 46.56/78.80 ± 50.30
94.20 ± 18.82/79.00 ± 40.68
91.00 ± 25.56/81.40 ± 43.00
CPK (IU/dL)
51.18 ± 21.02/29.48 ± 11.98
39.16 ± 16.76/26.78 ± 6.62
36.72 ± 13.05/23.10 ± 8.59
42.08 ± 16.89/22.00 ± 6.25
Creatinine (mg/dL)
0.30 ± 0.00/0.38 ± 0.11
0.32 ± 0.04/0.36 ± 0.05
0.30 ± 0.00/0.32 ± 0.04
0.28 ± 0.04/0.28 ± 0.04
Total bilirubin (mg/dL)
0.28 ± 0.08/0.38 ± 0.35
0.20 ± 0.00/0.34 ± 0.11
0.24 ± 0.05/0.30 ± 0.00
0.14 ± 0.05/0.42 ± 0.18
Total protein (g/dL)
6.18 ± 0.23/6.90 ± 0.71
6.32 ± 0.41/6.46 ± 0.66
6.18 ± 0.33/7.26 ± 0.48
6.08 ± 0.26/6.32 ± 0.83
Albumin (g/dL)
3.80 ± 0.23/4.74 ± 0.53
4.00 ± 0.19/4.40 ± 0.58
3.96 ± 0.17/5.18 ± 0.31
3.66 ± 0.15/4.22 ± 0.53
Globulin (g/dL)
2.38 ± 0.26/2.16 ± 0.31
2.32 ± 0.34/2.06 ± 0.11
2.22 ± 0.29/2.08 ± 0.37
2.42 ± 0.30/2.10 ± 0.44
Albumin/Globulin ratio
1.62 ± 0.25/2.22 ± 0.31
1.75 ± 0.22/2.13 ± 0.23
1.81 ± 0.28/2.55 ± 0.43
1.54 ± 0.24/2.06 ± 0.36
Phosphorus (mg/dL)
9.12 ± 1.61/7.12 ± 1.54
9.20 ± 1.30/7.38 ± 0.61
9.40 ± 1.20/7.00 ± 0.53
9.12 ± 1.05/7.68 ± 0.96
Calcium (mg/dL)
10.48 ± 0.73/10.58 ± 1.02
10.56 ± 0.85/10.68 ± 0.28
10.56 ± 0.80/11.26 ± 0.48
9.98 ± 0.34/11.08 ± 0.40
Sodium (mmol/dL)
14.06 ± 0.26/14.26 ± 0.17
13.98 ± 0.21/14.20 ± 0.07
14.22 ± 0.13/14.02 ± 0.08
14.34 ± 0.13/14.08 ± 0.11
Potassium (mmol/L)
5.68 ± 1.67/4.28 ± 0.97
6.50 ± 2.06/4.58 ± 0.88
5.58 ± 1.26/4.36 ± 1.10
4.60 ± 1.02/4.30 ± 0.78
Chloride (mmol/dL)
10.46 ± 0.21/10.74 ± 0.18
10.48 ± 0.16/10.54 ± 0.11
10.58 ± 0.0.29/10.68 ± 0.26
10.90 ± 0.14/10.66 ± 0.29
Rats (n = 5 per group each) were orally administered distilled water (Control) or fGT. The serum biochemical items are expressed as mean ± SD. versus the control group by the Scheffe test; versus the control group by the MW test. ALP = alkaline phosphatase; AST = aspartate aminotransferase; ALT = alanine aminotransferase; BUN = blood urea nitrogen; CPK = creatine phosphokinase; LDH = lactate dehydrogenase.
