Acute and Subchronic Oral Toxicity of Fermented Green Tea with Aquilariae Lignum in Rodents
Table 7
Relative organ weights after a repeated dose of fGT for 13 weeks.
Control (male/female)
fGT (male/female)
2.0 g/kg
1.0 g/kg
0.5 g/kg
Brain
0.40 ± 0.05/0.66 ± 0.04
0.41 ± 0.03/0.63 ± 0.06
0.39 ± 0.05/0.64 ± 0.04
0.41 ± 0.04/0.67 ± 0.04
Heart
0.27 ± 0.02/0.30 ± 0.02
0.27 ± 0.02/0.29 ± 0.02
0.28 ± 0.03/0.29 ± 0.03
0.28 ± 0.02/0.30 ± 0.03
Lymph node
0.01 ± 0.00/0.02 ± 0.01
0.01 ± 0.00/0.01 ± 0.00
0.01 ± 0.00/0.02 ± 0.01
0.01 ± 0.00/0.01 ± 0.01
Spleen
0.14 ± 0.01/0.19 ± 0.02
0.14 ± 0.02/0.18 ± 0.02
0.14 ± 0.01/0.18 ± 0.03
0.14 ± 0.01/0.18 ± 0.04
Thymus
0.06 ± 0.01/0.09 ± 0.01
0.08 ± 0.02/0.09 ± 0.02
0.07 ± 0.01/0.09 ± 0.02
0.06 ± 0.01/0.10 ± 0.01
Liver
2.42 ± 0.22/2.47 ± 0.19
2.60 ± 0.39/2.36 ± 0.05
2.53 ± 0.20/2.51 ± 0.34
2.39 ± 0.16/2.52 ± 0.32
Pancreas
0.19 ± 0.03/0.22 ± 0.02
0.22 ± 0.02/0.24 ± 0.06
0.18 ± 0.05/0.22 ± 0.02
0.19 ± 0.03/0.25 ± 0.05
Lung
0.27 ± 0.02/0.37 ± 0.02
0.27 ± 0.03/0.36 ± 0.03
0.28 ± 0.02/0.36 ± 0.03
0.28 ± 0.02/0.38 ± 0.03
Kidney
0.30 ± 0.03/0.30 ± 0.02
0.31 ± 0.03/0.28 ± 0.02
0.30 ± 0.05/0.28 ± 0.03
0.28 ± 0.01/0.30 ± 0.04
Adrenal gland
0.01 ± 0.00/0.02 ± 0.00
0.01 ± 0.00/0.01 ± 0.00
0.01 ± 0.00/0.02 ± 0.00
0.01 ± 0.00/0.02 ± 0.00
Urinary bladder
0.03 ± 0.01/0.03 ± 0.01
0.03 ± 0.01/0.03 ± 0.01
0.03 ± 0.01/0.03 ± 0.01
0.03 ± 0.00/0.03 ± 0.01
Testis
0.33 ± 0.04/—
0.33 ± 0.03/—
0.31 ± 0.04/—
0.40 ± 0.05/—
Epididymis
0.14 ± 0.01/—
0.14 ± 0.01/—
0.13 ± 0.01/—
0.15 ± 0.02/—
Prostate
0.18 ± 0.03/—
0.18 ± 0.03/—
0.19 ± 0.01/—
0.21 ± 0.05/—
Ovary
—/0.03 ± 0.01
—/0.03 ± 0.00
—/0.03 ± 0.01
—/0.04 ± 0.01
Uterus
—/0.23 ± 0.04
—/0.24 ± 0.10
—/0.27 ± 0.08
—/0.26 ± 0.09
Rats (n = 5 per group each) were orally administered distilled water (Control) or fGT. The relative organ weight to the body weight (%) is expressed as mean ± SD.
