Acute and Subchronic Oral Toxicity of Fermented Green Tea with Aquilariae Lignum in Rodents

Table 8

Histopathological abnormalities after a repeated oral dose of fGT for 13 weeks.

	Control (male/female)	fGT (male/female)
		2.0 g/kg	1.0 g/kg	0.5 g/kg
LN: LC hyperplasia +1	5/10 (2/5, 3/5)	7/10 (3/5, 4/5)	5/10 (2/5, 3/5)	5/10 (2/5, 3/5)
Spleen: LC decrease +1	2/10 (1/5, 1/5)	2/10 (1/5, 1/5)	3/10 (1/5, 2/5)	0/10 (0/5, 0/5)
Thymus: congestion +1	1/10 (1/5, 0/5)	1/10 (1/5, 0/5)	0/10 (0/5, 0/5)	0/10 (0/5, 0/5)
Liver: IF infiltration +1	4/10 (1/5, 3/5)	2/10 (1/5, 1/5)	3/10 (1/5, 2/5)	4/10 (1/5, 3/5)
Lung: congestion +1	4/10 (2/5, 2/5)	4/10 (2/5, 2/5)	3/10 (1/5, 2/5)	4/10 (2/5, 2/5)
Adrenal gland: congestion +1	1/10 (0/5, 1/5)	1/10 (0/5, 1/5)	0/10 (0/5, 0/5)	0/10 (0/5, 0/5)
Prostate
IF infiltration +1	2/5 (2/5, —)	1/5 (1/5, —)	2/5 (2/5, —)	1/5 (1/5, —)
Tubular atrophy +1	1/5 (1/5, —)	1/5 (1/5, —)	1/5 (1/5, —)	1/5 (1/5, —)
Pylorus: cyst +1	0/10 (0/5, 0/5)	0/10 (0/5, 0/5)	1/10 (0/5, 1/5)	0/10 (0/5, 0/5)

Rats (n = 5 per group each) were orally administered distilled water (Control) or fGT. The score +1 means slight abnormal changes. Rats showing the abnormalities are listed as a number per total number. LN = lymph nodes; LC = lymphoid cell; IF = inflammatory cell.