Research Article
Metabolite Markers for Characterizing Sasang Constitution Type through GC-MS and 1H NMR-Based Metabolomics Study
Figure 4
OPLS-DA score plots derived from 1H NMR spectra (a) and GC-MS data (c) of serum samples between underweight and obese people, and validations of the models by a permutation test repeated 200 times (b and d). Panel (e) shows a comparison of metabolites that are significantly different according to BMI regardless of SC type. Subjects were classified into underweight (BMI < 18.5, n=8), normal weight (BMI, 18.5-22.9, n=44), overweight (BMI, 23.0-24.9, n=20), and obese (BMI > 25.0, n=20). Panel (f) shows difference in serum lactate contents between Tae-Eum and So-Yang types with normal weight and overweight, demonstrating metabolic dependence of serum lactate level on SC types. Values are presented as mean ± SD. Different alphabets indicate significant differences among groups by Duncan’s test at p < 0.05. UW, underweight; NW, normal weight; OW, overweight; OB, obese.
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