Circulating Hypoxia Responsive microRNAs (HRMs) and Wound Healing Potentials of Green Tea in Diabetic and Nondiabetic Rat Models

Table 2

Effect of green tea extract on % wound contraction and epithelialization period of wound in excision wound model.

Group	% wound contraction					Epithelialization period (days)
	day	day	day	day	Scar area (mm^2)
Group I	186.8 ± 0.75	142.2± 0.98 (25%)	65.9 ± 2.56 (46%)	38.7 ±1.23 (63%)	99.6±3.9	20.9 ± 0.65
Group II	192.2 ± 0.39	151±3.4 (21.9 %)	85.7± 0.98 (41.8 %)	55.6 ±2.7 (61.9 %)	94.8±5.4	22.6 ± 0.45
GroupIII	188.6 ± 0.28	132.3±1.5 (34.6%)	45.9 ± 1.37 (68 %)	28.9 ±1.3 (83.1%)	99.8±2.5	13.8± 0.23
GroupIV	194.6 ± 1.2	128 ± 1.4 (35.1 %)	56.1± 0.98 (66.8%)	22.8 ±0.3 (81.9 %)	98.6±1.8	14.5 ± 0.28
Group V	193.9 ± .98	168 ± 0.45 (16.1 %)	75.3 ± 1.2 (43.5 %)	22.8 ±0.3 (78.6%)	92.3±3.9	15.8 ± 1.4

P < 0.05, P < 0.01, and P < 0.001. All values are represented as mean ± SD, = 8 animals in each group. Data were analyzed by one-way ANOVA, followed by Tukey-Kramer Multiple Comparisons Test. Group I: vaseline treated normal control rats, group II: diabetic rats treated with vaseline, group III: normal control rats treated with vaseline plus 0.6 green tea extract, group IV: diabetic rats treated with vaseline plus 0.6 green tea extract, and group V: standard control rats treated with betadine 5% w/w povidone iodine cream.