Research Article
iTRAQ-Based Proteomics Analysis of Plasma of Myasthenia Gravis Patients Treated with Jia Wei Bu Zhong Yi Qi Decoction
Table 4
Interacted proteins with combined score ≥0.9.
| Node1 | Node2 | Homology | Coexpression | Experimentally_determined_interaction | Database_annotated | Automated_textmining | Combined_score |
| MYL6 | MYH9 | 0 | 0.64 | 0.858 | 0.9 | 0.711 | 0.998 | APOA2 | APOC3 | 0 | 0.796 | 0 | 0.9 | 0.86 | 0.996 | TUBB | TUBA1A | 0.92 | 0.227 | 0.948 | 0.9 | 0.591 | 0.995 | AHSG | APOA2 | 0 | 0.918 | 0 | 0.9 | 0.455 | 0.995 | APOA5 | APOC3 | 0 | 0.466 | 0 | 0.9 | 0.86 | 0.991 | TUBB | TUBA4A | 0.92 | 0.189 | 0.881 | 0.9 | 0.679 | 0.99 | APOA4 | APOC3 | 0 | 0.565 | 0 | 0.9 | 0.789 | 0.99 | AHSG | ITIH2 | 0 | 0.841 | 0 | 0.9 | 0.439 | 0.99 | AHSG | HRG | 0 | 0.67 | 0 | 0.9 | 0.644 | 0.987 | AHSG | TF | 0 | 0.68 | 0 | 0.9 | 0.571 | 0.985 | AHSG | IGFBP1 | 0 | 0.788 | 0 | 0.9 | 0.25 | 0.982 | TF | APOA2 | 0 | 0.675 | 0 | 0.9 | 0.502 | 0.982 | TUBA1A | TUBA4A | 0.986 | 0 | 0.809 | 0.9 | 0.58 | 0.98 | CD14 | LBP | 0 | 0.063 | 0.379 | 0.9 | 0.712 | 0.98 | ILK | RSU1 | 0 | 0.265 | 0.925 | 0 | 0.674 | 0.98 | PF4 | PPBP | 0.886 | 0.786 | 0 | 0.9 | 0.922 | 0.98 | VWF | THBS1 | 0 | 0.063 | 0 | 0.9 | 0.785 | 0.978 | C1R | C4A | 0 | 0.183 | 0.05 | 0.9 | 0.746 | 0.977 | AHSG | PROC | 0 | 0.742 | 0 | 0.9 | 0.128 | 0.975 | APOA2 | ITIH2 | 0 | 0.728 | 0 | 0.9 | 0.128 | 0.974 | THBS1 | HRG | 0 | 0 | 0.379 | 0.9 | 0.609 | 0.973 | SERPINA5 | PROC | 0 | 0.177 | 0.435 | 0.9 | 0.416 | 0.969 | APOA5 | APOA2 | 0 | 0.399 | 0 | 0.9 | 0.526 | 0.969 | C1R | C1QC | 0 | 0.119 | 0 | 0.9 | 0.666 | 0.968 | PF4 | VWF | 0 | 0.061 | 0 | 0.9 | 0.685 | 0.967 | TF | ITIH2 | 0 | 0.578 | 0 | 0.9 | 0.297 | 0.967 | HIST1H4A | HIST3H3 | 0 | 0.107 | 0.494 | 0.9 | 0.371 | 0.967 | TF | CP | 0 | 0.181 | 0 | 0.9 | 0.636 | 0.967 | PPBP | VWF | 0 | 0.061 | 0 | 0.9 | 0.669 | 0.966 | MYL6 | TPM4 | 0 | 0.185 | 0.185 | 0.9 | 0.546 | 0.965 | APOA2 | IGFBP1 | 0 | 0.645 | 0 | 0.9 | 0.101 | 0.965 | ACTN1 | TLN1 | 0 | 0.116 | 0.083 | 0.9 | 0.622 | 0.965 | APOA2 | APOA4 | 0 | 0.115 | 0 | 0.9 | 0.626 | 0.964 | AHSG | CP | 0 | 0.157 | 0 | 0.9 | 0.609 | 0.964 | ILK | HSP90AA1 | 0 | 0 | 0.161 | 0.9 | 0.584 | 0.962 | C8A | C9 | 0.781 | 0.341 | 0.379 | 0.9 | 0.576 | 0.96 | APOA5 | AHSG | 0 | 0.556 | 0 | 0.9 | 0.189 | 0.96 | C4A | C1QC | 0 | 0.16 | 0 | 0.9 | 0.551 | 0.959 | ITIH2 | PROC | 0 | 0.593 | 0 | 0.9 | 0.05 | 0.957 | C4A | APOA2 | 0 | 0.083 | 0.379 | 0.9 | 0.308 | 0.955 | PF4 | THBS1 | 0 | 0.06 | 0 | 0.9 | 0.561 | 0.955 | ITIH2 | IGFBP1 | 0 | 0.554 | 0 | 0.9 | 0 | 0.953 | ADIPOQ | CRP | 0 | 0 | 0 | 0 | 0.952 | 0.952 | TUBB | HSP90AA1 | 0 | 0.129 | 0.13 | 0.9 | 0.411 | 0.949 | HSP90AA1 | TUBA1A | 0 | 0.062 | 0.305 | 0.9 | 0.305 | 0.948 | APOA2 | PON1 | 0 | 0.141 | 0 | 0.72 | 0.794 | 0.946 | APOA2 | CP | 0 | 0.115 | 0 | 0.9 | 0.44 | 0.946 | MYL6 | TLN1 | 0 | 0.427 | 0 | 0.9 | 0.135 | 0.946 | APOA5 | TF | 0 | 0.175 | 0 | 0.9 | 0.406 | 0.946 | C4A | TF | 0 | 0.159 | 0 | 0.9 | 0.405 | 0.945 | PF4 | HRG | 0 | 0 | 0 | 0.9 | 0.471 | 0.944 | ILK | ACTN1 | 0 | 0.064 | 0.133 | 0.9 | 0.38 | 0.943 | PF4 | PROC | 0 | 0 | 0.379 | 0.9 | 0.164 | 0.943 | TF | IGFBP1 | 0 | 0.214 | 0.313 | 0.9 | 0.073 | 0.943 | CP | PROC | 0 | 0.111 | 0.379 | 0.9 | 0.09 | 0.943 | PLTP | APOA2 | 0 | 0 | 0.379 | 0.72 | 0.7 | 0.943 | APOA5 | IGFBP1 | 0 | 0.394 | 0 | 0.9 | 0.126 | 0.942 | ITIH2 | CP | 0 | 0.24 | 0 | 0.9 | 0.289 | 0.941 | APOA5 | ITIH2 | 0 | 0.428 | 0 | 0.9 | 0 | 0.94 | C4A | CP | 0 | 0.159 | 0 | 0.9 | 0.35 | 0.94 | FLNA | VWF | 0 | 0.061 | 0.085 | 0.9 | 0.38 | 0.939 | ITIH2 | FETUB | 0 | 0.916 | 0 | 0 | 0.31 | 0.939 | C1R | CRP | 0 | 0.061 | 0 | 0.9 | 0.399 | 0.938 | APOC3 | CETP | 0 | 0.06 | 0 | 0.72 | 0.785 | 0.938 | APOA5 | C4A | 0 | 0.106 | 0 | 0.9 | 0.363 | 0.938 | C4A | AHSG | 0 | 0.148 | 0 | 0.9 | 0.322 | 0.937 | APOA5 | APOA4 | 0.681 | 0.197 | 0 | 0.9 | 0.802 | 0.937 | IGFBP3 | IGFBP1 | 0.755 | 0.214 | 0 | 0.9 | 0.929 | 0.936 | VWF | PROC | 0 | 0 | 0 | 0.9 | 0.392 | 0.936 | PPBP | THBS1 | 0 | 0.062 | 0 | 0.9 | 0.363 | 0.935 | EFEMP1 | FBLN1 | 0.72 | 0.16 | 0.12 | 0.9 | 0.709 | 0.935 | TF | IGFBP3 | 0 | 0.096 | 0.313 | 0.9 | 0.057 | 0.933 | HSP90AA1 | TUBA4A | 0 | 0.055 | 0 | 0.9 | 0.342 | 0.932 | C4A | ITIH2 | 0 | 0.177 | 0 | 0.9 | 0.237 | 0.931 | APOA5 | PROC | 0 | 0.338 | 0 | 0.9 | 0 | 0.931 | SERPINA5 | VWF | 0 | 0 | 0 | 0.9 | 0.31 | 0.928 | C4A | PROC | 0 | 0.128 | 0.05 | 0.9 | 0.231 | 0.927 | VWF | HRG | 0 | 0.06 | 0 | 0.9 | 0.292 | 0.927 | TLN1 | VWF | 0 | 0.055 | 0 | 0.9 | 0.282 | 0.926 | APOA2 | PROC | 0 | 0.275 | 0 | 0.9 | 0.062 | 0.926 | IGFBP1 | PROC | 0 | 0.287 | 0 | 0.9 | 0 | 0.925 | AHSG | IGFBP3 | 0 | 0.152 | 0 | 0.9 | 0.197 | 0.925 | TPM4 | TLN1 | 0 | 0.089 | 0 | 0.9 | 0.247 | 0.925 | APOA5 | CETP | 0 | 0.061 | 0 | 0.72 | 0.735 | 0.924 | APOA2 | CETP | 0 | 0 | 0 | 0.72 | 0.738 | 0.923 | IGFBP1 | CP | 0 | 0.146 | 0 | 0.9 | 0.164 | 0.922 | C4A | C8A | 0 | 0.127 | 0 | 0 | 0.914 | 0.922 | PPBP | HRG | 0 | 0 | 0 | 0.9 | 0.25 | 0.921 | ITIH3 | ITIH4 | 0.896 | 0.18 | 0 | 0.9 | 0.718 | 0.92 | ACTN1 | THBS1 | 0 | 0.098 | 0 | 0.9 | 0.186 | 0.92 | C1QC | CRP | 0 | 0 | 0 | 0.9 | 0.236 | 0.92 | SAA1 | PF4 | 0 | 0.061 | 0 | 0.9 | 0.195 | 0.917 | SAA1 | PPBP | 0 | 0.063 | 0 | 0.9 | 0.195 | 0.917 | ACTN1 | VWF | 0 | 0.061 | 0.17 | 0.9 | 0.066 | 0.917 | IGFBP3 | APOA2 | 0 | 0.141 | 0 | 0.9 | 0.107 | 0.916 | AHSG | THBS1 | 0 | 0 | 0 | 0.9 | 0.189 | 0.915 | TF | HSP90B1 | 0 | 0 | 0 | 0.9 | 0.168 | 0.913 | TF | PROC | 0 | 0.147 | 0.067 | 0.9 | 0 | 0.913 | C4A | IGFBP1 | 0 | 0.116 | 0 | 0.9 | 0.096 | 0.913 | PON1 | CETP | 0 | 0 | 0 | 0.72 | 0.703 | 0.913 | AHSG | PF4 | 0 | 0 | 0 | 0.9 | 0.161 | 0.912 | AHSG | VWF | 0 | 0.057 | 0 | 0.9 | 0.144 | 0.912 | APOA5 | CP | 0 | 0.116 | 0 | 0.9 | 0.071 | 0.91 | APOA2 | HSP90B1 | 0 | 0 | 0 | 0.9 | 0.135 | 0.909 | IGFBP3 | ITIH2 | 0 | 0.112 | 0 | 0.9 | 0 | 0.907 | C4A | IGFBP3 | 0 | 0.095 | 0 | 0.9 | 0.061 | 0.907 | AHSG | PPBP | 0 | 0 | 0 | 0.9 | 0.111 | 0.907 | HSP90B1 | CP | 0 | 0.077 | 0 | 0.9 | 0.08 | 0.907 | IGFBP3 | CP | 0 | 0.076 | 0 | 0.9 | 0.076 | 0.907 | ACTN1 | PF4 | 0 | 0 | 0 | 0.9 | 0.116 | 0.907 | ACTN1 | PPBP | 0 | 0 | 0 | 0.9 | 0.111 | 0.907 | ITIH2 | HSP90B1 | 0 | 0 | 0 | 0.9 | 0.104 | 0.906 | IGFBP3 | HSP90B1 | 0 | 0 | 0 | 0.9 | 0.093 | 0.905 | APOA5 | IGFBP3 | 0 | 0.069 | 0 | 0.9 | 0.061 | 0.904 | AHSG | HSP90B1 | 0 | 0 | 0 | 0.9 | 0.072 | 0.903 | C4A | HSP90B1 | 0 | 0.061 | 0 | 0.9 | 0.042 | 0.902 | IGFBP3 | PROC | 0 | 0.062 | 0 | 0.9 | 0 | 0.902 | AHSG | ACTN1 | 0 | 0 | 0 | 0.9 | 0.058 | 0.901 | HSP90B1 | IGFBP1 | 0 | 0 | 0 | 0.9 | 0.058 | 0.901 | HSP90B1 | PROC | 0 | 0 | 0 | 0.9 | 0 | 0.9 | APOA5 | HSP90B1 | 0 | 0 | 0 | 0.9 | 0 | 0.9 | ACTN1 | HRG | 0 | 0 | 0 | 0.9 | 0 | 0.9 |
|
|