Adenine Inhibits the Growth of Colon Cancer Cells via AMP-Activated Protein Kinase Mediated Autophagy

<div>Adenine-induced autophagic inhibition on colon cancer cells via AMPK activation. (a) After pretreatment with dorsomorphin (5 <i>μ</i>M), colon cancer cells HT29 and Caco-2 were treated with adenine (10 mM) for 24 h . Levels of p-AMPK and p-mTOR were measured by western blotting. (b) Viabilities of cells receiving different treatments were evaluated using the MTT assay.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 5

Figure 5: Adenine Inhibits the Growth of Colon Cancer Cells via AMP-Activated Protein Kinase Mediated Autophagy 