Review Article

Meta-Analysis on the Efficacy and Safety of Traditional Chinese Medicine as Adjuvant Therapy for Refractory Androgenetic Alopecia

Table 4

The details of the 30 Chinese herbal formulas.

StudyFormulaIngredients/percentagesPreparation methods

Yang et al. [24]ShengFa
Lotion
Salviae Miltiorrhizae Radix (1.7%), Polygoni multiflori Radix (1.25%), Sophorae Flavescentis Radix (1.25%), Zanthoxylum bungeanum (0.8%), AES (15%), AS (5%), BS-12(5%), inorganic additive (10%), glycol distearate (3%), silicone oil (1%), flavours (1%), water (53%)(1) Diacolation with 5000 ml 95% ethanol
(2) Concentrated to a thin extract

Chien et al. [25]BeauTop
Tablet
Rehmanniae Radix, Angelicae Sinensis Radix, Ecliptae Herba, Ginseng Radix, Astragali Radix, Ligustri FructusProduced by Sun Ten Pharmaceutical (Taipei, China)

Liang [26]YuFaYe
Lotion
Angelicae Sinensis Radix, Chuanxiong Rhizoma, Zanthoxylum bungeanum Maxim, Carthami Flos, Zingiberis RhizomaProduced by Bawang Co. LTD (Guangzhou, China)

Yang [27]YiRen QuShi
Decoction
Rehmanniae Radix (15 g), Salviae Miltiorrhizae Radix (15 g), Platycladi Cacumen (15 g), Poria (10 g), Crataegi Fructus (15 g), Alismatis Rhizoma (10 g), Moutan Cortex (10 g), Lycopi Herba (10 g), Acori Tatarinowii Rhizoma (10 g), Artemisiae Scopariae Herba (10 g), Chaenomelis Fructus (10 g), Liuyi powder (10 g), Coicis Semen (10 g)Decocted with water

Wu et al. [28]TuoFaFang
Decoction
Angelicae Sinensis Radix (15 g), Polygoni multiflori Radix (15 g), Platycladi Cacumen (15 g), Chuanxiong Rhizoma (15 g), Cinnamomi Ramulus (15 g), Viticis Fructus (15 g), Puerariae Lobatae Radix (30 g)Decocted with water

Dai [29]QuShi ShengFaFang
Decoction
Rehmanniae Radix (15 g), Salviae Miltiorrhizae Radix (15 g), Chuanxiong Rhizoma (10 g), Platycladi Cacumen (15 g), Crataegi Fructus (15 g), Glycyrrhizae Radix et Rhizoma (5 g), Poria (10 g), Alismatis Rhizoma (10 g), Moutan Cortex (10 g), Chaenomelis Fructus (10 g), Coicis Semen (15 g), Lycopi Herba (10 g)Decocted with water

Wu et al. [30]QuShi ShengFa
Decoction
Rehmanniae Radix (15 g), Salviae Miltiorrhizae Radix (15 g), Poria (10 g), Platycladi Cacumen (15 g), Crataegi Fructus (15 g), Alismatis Rhizoma (10 g), Moutan Cortex (10 g), Lycopi Herba (10 g), Acori Tatarinowii Rhizoma (10 g), Artemisiae Scopariae Herba (10 g), Chaenomelis Fructus (10 g), Liuyi powder (10 g), Coicis Semen (15 g)Decocted with water

Sui [31]QuZhi GuTuoYin
Decoction
Salviae Miltiorrhizae Radix (20 g), Polygoni multiflori Radix (15 g), Glycyrrhizae Radix et Rhizoma (6 g), Crataegi Fructus (15 g), Poria (30 g), Ligustri Lucidi Fructus (15 g), Moutan Cortex (10 g), Cuscutae Semen (12 g), Sophorae Flavescentis Radix (10 g), Astragali Radix (15 g), Polyporus (15 g), Lycii Fructus (10 g), Psoraleae Fructus (12 g), Ziziphi Spinosae Semen (15 g)Decocted with water

Wang et al. [32]QuShi JianFaYin
Decoction
Rehmanniae Radix (20 g), Chuanxiong Rhizoma (15 g), Alismatis Rhizoma (15 g), Mori Fructus (15 g), Polyporus (25 g), Tuber Fleeceflower Stem (25 g), Dioscoreae Tokoro Rhizoma (25 g), Plantaginis Semen (15 g), Dictamni Cortex (25 g), Atractylodis Macrocephalae Rhizoma (25 g), Halloysitum Rubrum (20 g)Decocted with water

Li et al. [33]ShengFa Pill
Decoction
Rehmanniae Radix (12–30 g), Salviae Miltiorrhizae Radix (15–30 g), Angelicae Sinensis Radix (10 g), Crataegi Fructus (10 g), Chuanxiong Rhizoma (10 g), Alismatis Rhizoma (10 g), Cuscutae Semen (12 g), Chaenomelis Fructus (6 g), Ziziphi Spinosae Semen (15–20 g), Paeoniae Radix Alba (12 g), Polygoni Multiflori Caulis (15 g), Carthami Flos (6–10 g), Cimicifugae Rhizoma (3 g), Atractylodis Macrocephalae Rhizoma (10–15 g)Decocted with water

Wang and Zhang [34]QuZhi ShengFaYin
Decoction
Salviae Miltiorrhizae Radix (30 g), Polygoni multiflori Radix (15 g), Poria (20 g), Crataegi Fructus (15 g), Ligustri Lucidi Fructus (15 g), Glycyrrhizae Radix et Rhizoma (10 g), Mori Fructus (15 g), Alismatis Rhizoma (15 g), Moutan Cortex (15 g), Taraxaci Herba (25 g), Oldenlandia diffusa Herba (30 g), Coicis Semen (40 g), Gardenia jasminoides (20 g), Dictamni Cortex (20 g)Decocted with water

He and Liang [35]DiHuang ShengFaLing
Decoction
Rehmanniae Radix (200 g), Ligustri Lucidi Fructus (150 g), Chuanxiong Rhizoma (40 g), Ecliptae Herba (100 g), Carthami Flos (40 g), Psoraleae Fructus (150 g), Cordyceps (20 g), Ginseng Radix (50 g), Achyranthis bidentate Radix (50 g), Morindae Officinalis Radix (120 g), Polygonati Rhizoma (120 g)Produced by Jingchuan Hospital of Traditional Chinese Medicine, Gansu, China

Mo [36]QuZhi ShengFa
Lotion
Platycladi Cacumen, Garden Balsam Stem, Sophorae Flavescentis Radix, Polygonati Rhizoma, Gleditsiae Fructus, 0.2% sodium benzoateProduced by Hunan University of Traditional Chinese Medicine, Changsha, China

Zhang [37]JiaWei ErZhiWan
Decoction
Rehmanniae Radix (15 g), Salviae Miltiorrhizae Radix (20 g), Polygoni multiflori Radix (20 g), Poria (10 g), Ligustri Lucidi Fructus (20 g), Glycyrrhizae Radix et Rhizoma (6 g), Alismatis Rhizoma (10 g), Moutan Cortex (10 g), Ecliptae Herba (20 g), Paeoniae Radix Alba (15 g), Sesami Semen Nigrum (15 g), Juglandis Semen (12 g), Corni Fructus (12 g)Decocted with water

Liu and Sun [38]YiShen ShengFaTang
Decoction
Rehmanniae Radix (20 g), Angelicae Sinensis Radix (10 g), Polygoni multiflori Radix (15 g), Poria (10 g), Ligustri Lucidi Fructus (20 g), Platycladi Cacumen (15 g), Glycyrrhizae Radix et Rhizoma (10 g), Cuscutae Semen (20 g), Ecliptae Herba (15 g), Lycii Fructus (10 g), Polygonati Rhizoma (15 g), Ziziphi Spinosae Semen (30 g)Decocted with water

Bao et al. [39]Gao Fang
Decoction
Rehmanniae Radix (30 g), Salviae Miltiorrhizae Radix (15 g), Angelicae Sinensis Radix (20 g), Polygoni multiflori Radix (20 g), Poria (20 g), Ligustri Lucidi Fructus (10 g), Crataegi Fructus (15 g), Chuanxiong Rhizoma (20 g), Chuanxiong Rhizoma (20 g), Mori Fructus (20 g), Ecliptae Herba (10 g), Psoraleae Fructus (20 g), Dioscoreae Rhizoma (15 g), Paeoniae Radix Alba (20 g), Bupleuri Radix (15 g), Gastrodiae Rhizoma (10 g), Uncariae Ramulus Cum Uncis (10 g), Acori Tatarinowii Rhizoma (20 g), Atractylodis Macrocephalae Rhizoma (30 g), Citri Reticulatae Pericarpium (20 g), Massa Medicata Fermentata (15 g)Decocted with water

Wang [40]BuShen ZiYing Fang
Decoction
Salviae Miltiorrhizae Radix (30 g), Angelicae Sinensis Radix (15 g), Polygoni multiflori Radix (15 g), Poria (15 g), Ligustri Lucidi Fructus (30 g), Glycyrrhizae Radix et Rhizoma (10 g), Mori Fructus (15 g), Cuscutae Semen (15 g), Ecliptae Herba (30 g), Lycii Fructus (10 g), Astragali Radix (15 g), Taxilli Herba (15 g)Decocted with water

Xiang [41]ZhaQu PinWeiSan He Er ZhiWan
Decoction
Salviae Miltiorrhizae Radix (30 g), Polygoni multiflori Radix (30 g), Ligustri Lucidi Fructus (30 g), Crataegi Fructus (30 g), Glycyrrhizae Radix et Rhizoma (6 g), Platycladi Cacumen (30 g), Ecliptae Herba (15 g), Massa Medicata Fermentata (20 g), Sophorae Flos (30 g), Atractylodis Rhizoma (10 g), Magnoliae officinalis Cortex (15 g), Citri Reticulatae Pericarpium (15 g), Acori Tatarinowii Rhizoma (10 g)Decocted with water

Xiang [42]Tanshinone
Capsule
Salviae Miltiorrhizae RadixProduced by Hebei Xinglong Xili Pharmaceutical Co. LTD, China

Lin [43]Qibao beards folk prescription
Decoction
Rehmanniae Radix (12 g), Salviae Miltiorrhizae Radix (15 g), Angelicae Sinensis Radix (15 g), Polygoni multiflori Radix (18 g), Poria (12 g), Platycladi Cacumen (10 g), Ligustri Lucidi Fructus (18 g), Mori Fructus (18 g), Cuscutae Semen (15 g), Lycii Fructus (10 g), Achyranthis Bidentatae Radix (12 g), Scutellariae Radix (12 g), Astragali Radix (15 g)Decocted with water

Gong [44]JiaWei HuangLian EJiao
Decoction
Rehmanniae Radix (12 g), Salviae Miltiorrhizae Radix (12 g), Polygoni multiflori Radix (12 g), Coptidis Rhizoma (12 g), Sophorae Flavescentis Radix (12 g), Paeoniae Radix Alba (12 g), Scutellariae Radix (9 g), Gastrodiae Rhizoma (9 g), Asini Corii Colla (10 g), Hen egg yolk (2#)Decocted with water

Xi et al. [45]GuShen ShengFaTang
Decoction
Rehmanniae Radix (20 g), Salviae Miltiorrhizae Radix (20 g), Polygoni multiflori Radix (15 g), Platycladi Cacumen (15 g), Crataegi Fructus (20 g), Poria (20 g), Glycyrrhizae Radix et Rhizoma (6 g), Ligustri Lucidi Fructus (20 g), Mori Fructus (20 g), Ecliptae Herba (15 g), Taraxaci Herba (20 g), Concha ostreae (30 g), Mori Cortex (15 g), Oldenlandia diffusa Herba (15 g), Bupleuri Radix (10 g)Decocted with water

Xia and Liu [46]ZiNi ZiShen YangXue ShengFaTang
Decoction
Rehmanniae Radix (15 g), Salviae Miltiorrhizae Radix (20 g), Angelicae Sinensis Radix (15 g), Polygoni multiflori Radix (15 g), Poria (30 g), Ligustri Lucidi Fructus (15 g), Glycyrrhizae Radix et Rhizoma (20 g), Chuanxiong Rhizoma (20 g), Mori Fructus (20 g), Cuscutae Semen (15 g), Ecliptae Herba (15 g), Dioscoreae Rhizoma (15 g), Paeoniae Radix Alba (10 g), Astragali Radix (15 g), Spatholobi Caulis (20 g), Ziziphi Spinosae Semen (20 g), Tuber Fleeceflower Stem (20 g), Corni Fructus (20 g), Lycii Fructus (20 g), Eucommiae Cortex (15 g), Polygonati Rhizoma (15 g), Taraxaci Herba (20 g)Decocted with water

Ye and Qi [47]YangXue ShengFa HeJi
Decoction
Angelicae Sinensis Radix, Polygoni multiflori Radix, Poria, Cuscutae Semen, Lycii Fructus, Achyranthis Bidentatae Radix, Psoraleae FructusProduced by Kunming Hospital of Traditional Chinese Medicine

Xi et al. [48]QuZhi ShengFa
Pill
Rehmanniae Radix, Salviae Miltiorrhizae Radix, Polygoni multiflori Radix, Platycladi Cacumen, Crataegi Fructus, Poria, Glycyrrhizae Radix et Rhizoma, Ligustri Lucidi Fructus, Mori Fructus, Ecliptae Herba, Taraxaci Herba, Ostreae Concha, Mori Cortex, Oldenlandia diffusa Herba, Bupleuri RadixProduced by Hunan University of Traditional Chinese Medicine, Changsha, China

Wang et al. [49]Fukang mixture
Decoction
Poria (30 g), Crataegi Fructus (30 g), Moutan Cortex (10 g), Scutellariae Radix (15 g), Platycodonis Radix (6 g), Taraxaci Herba (30 g), Bupleuri Radix (10 g), Oldenlandia diffusa Herba (20 g), Paeoniae Radix Rubra (30 g), Sophorae Flos (10 g), Dictamni Cortex (15 g), Prunellae Spica (10 g), gypsum (30 g)Decocted with water

Fang [50]ShengFa
Decoction
Rehmanniae Radix (20 g), Angelicae Sinensis Radix (15 g), Ligustri Lucidi Fructus (10 g), Moutan Cortex (15 g), Cuscutae Semen (20 g), Ecliptae Herba (30 g), Scutellariae Radix (15 g), Mori Cortex (15 g), Schizonepetae Herba (15 g), Saposhnikoviae Radix (10 g), Coicis Semen (30 g), Cicadae Periostracum (10 g)Decocted with water

Xie [51]JianWei YiShen QuShi ShengFa
Decoction
Rehmanniae Radix (15 g), Poria (15 g), Glycyrrhizae Radix et Rhizoma (6 g), Crataegi Fructus (10 g), Ligustri Lucidi Fructus (15 g), Alismatis Rhizoma (10 g), Ecliptae Herba (15 g), Atractylodis Macrocephalae Rhizoma (10 g), Artemisiae Scopariae Herba (15 g), Dictamni Cortex (10 g), Coicis Semen (15 g)Decocted with water

Liu [52]Quzhi Fangtuo shengfa ying
Decoction
Angelicae Sinensis Radix (15 g), Ligustri Lucidi Fructus (15 g), Glycyrrhizae Radix et Rhizoma (6 g), Poria (15 g), Platycladi Cacumen (10 g), Chuanxiong Rhizoma (15 g), Alismatis Rhizoma (10 g), Ecliptae Herba (15 g), Coicis Semen (15 g), Puerariae Radix (15 g), Tribuli Fructus (15 g), Dioscoreae Tokoro Rhizoma (10 g), Rubi Fructus (15 g)Decocted with water

Xu et al. [53]ShengFa Ting
Decoction
Salviae Miltiorrhizae Radix (60 g), Psoraleae Fructus (60 g), Astragali Radix (60 g), Carthami Flos (40 g), Zingiberis Rhizoma (60 g), Cinnamomum camphora (50 g)Diacolation with 1000 ml 60% ethanol

Bold values represent the top 15 commonly used herbs, which have been listed in Table 5.