Comparative Pharmacokinetic Study of Taxifolin after Oral Administration of Fructus Polygoni Orientalis Extract in Normal and Fibrotic Rats by UPLC-MS/MS

Table 5

Stability of taxifolin in rat plasma under a variety of storage conditions (n = 3).

Spiked concentration (ng/mL)	Room temperature for 24 h		Three freeze-thaw cycles		−20°C for 1 month
	Measured concentration (ng/mL)	RE (%)	Measured concentration (ng/mL)	RE (%)	Measured concentration (ng/mL)	RE (%)
50	49.7 ± 4.9	−0.7	50.9 ± 1.1	1.7	51.1 ± 2.2	2.1
1000	1021.7 ± 41.8	2.2	963.4 ± 45.7	−3.7	949.3 ± 34.4	−5.1
4000	3846.3 ± 99.5	−3.8	3878.3 ± 89.9	−3.0	3766.7 ± 120.2	−5.8