Sesamin, a Naturally Occurring Lignan, Inhibits Ligand-Induced Lipogenesis through Interaction with Liver X Receptor Alpha (LXR<i>α</i>) and Pregnane X Receptor (PXR)

<div>Molecular docking analysis of T0901317 (T090) and sesamin (SSM) with LXR<i>α</i>. Superimposition of docking posed of compounds in the LXR<i>α</i>-binding pocket of 3D structure (PDB entry 1UHL). (a) Pose 3D structure of agonist T090 in the active site of LXR<i>α</i> ligand-binding domain. (b) Docking pose of SSM in the active site of LXR<i>α</i> ligand-binding domain.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 3: Sesamin, a Naturally Occurring Lignan, Inhibits Ligand-Induced Lipogenesis through Interaction with Liver X Receptor Alpha (LXR<i>α</i>) and Pregnane X Receptor (PXR) 

Figure 3 | Sesamin, a Naturally Occurring Lignan, Inhibits Ligand-Induced Lipogenesis through Interaction with Liver X Receptor Alpha (LXRα) and Pregnane X Receptor (PXR) 