Effect of Electroacupuncture on Hyperalgesia and Vasoactive Neurotransmitters in a Rat Model of Conscious Recurrent Migraine
Figure 4
Plasma levels of vasoactive neurotransmitters in the six groups. Vasoactive neurotransmitter release was significantly higher in Model group rats with migraine than in those of the sham-operated group. Electroacupuncture reduced the release of CGRP (a), SP (b), VIP (c), PACAP (d), NO (f), and ET-1 (g), while nonacupuncture point treatment had no effect on the levels of these vasoactive neurotransmitters in rats with migraine. No variations in plasma NPY levels were observed among the six groups. Data are presented as the mean ± standard deviation, n=10/group. ∗P<0.05. CGRP: calcitonin gene-related peptide; PACAP: pituitary adenylate cyclase-activating polypeptide; NO: nitric oxide; SP: substance P; NPY: neuropeptide Y; VIP: vasoactive intestinal peptide; ET-1: endothelin-1.