Antimetastasis Effect of Astragalus membranaceus-Curcuma zedoaria via β-Catenin Mediated CXCR4 and EMT Signaling Pathway in HCT116

Figure 3

Decreased EMT signal, CXCR4 signal, and β-catenin signal are related to the inhibition of HQEZ on HCT116 cells. (a) The activation of AKT and ERK was not affected by the administration of HQEZ. (b) The administration of HQEZ inhibited the EMT signaling pathway which relates to the metastasis. (c) The administration of HQEZ reduced the expression of CXCR4, an important receptor mediating liver metastasis. (d) The administration of HQEZ induced degradation of β-catenin and the downregulation of its downstream factors. , p<0.05 compared with vehicle.