Effects of Hibiscus Sabdariffa Calyces Aqueous Extract on the Antihypertensive Potency of Captopril in the Two-Kidney-One-Clip Rat Hypertension Model

Figure 3

Effects of 2K1C surgery and subsequent antihypertensive drug treatments on plasma renin (a), serum ACE activity (b), and plasma angiotensin II (c). SHAM: normal control; 2K1C: negative control (no treatment); CAP: positive control (4.5 mg/200 g BW captopril; p.o.); HS: Hibiscus sabdariffa extract (30 mg/200 g BW; p.o.); CD 1: coadministration of dose 1 (Hibiscus sabdariffa extract 15 mg/200 g BW + captopril 4.5 mg/200 g BW; p.o.); CD 2: coadministration of dose 2 (Hibiscus sabdariffa extract 30 mg/200 g BW + captopril 4.5 mg/200 g BW; p.o.); CD 3: coadministration of dose (Hibiscus sabdariffa extract 60 mg/200 g BW + captopril 4.5 mg/200 g BW; p.o.). P < 0.05 compared to the 2K1C group; ^#P < 0.05 compared to the CAP group.

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(b)

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