Review Article

Efficacy and Safety of Fuzi Formulae on the Treatment of Heart Failure as Complementary Therapy: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials

Table 2

The element of Fuzi formula in each included study.

Included trialsFormulaIngredientDosage (g)
Latin nameEnglish nameChinese name

Huo et al. [19]Huaxinsu granule(1) Aconitum carmichaelii Debx.
(2) Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao and Astragalus membranaceus (Fisch.) Bge.
(3) Salvia miltiorrhiza Bge.
(4) Paeonia lactiflora Pall.
(5) Ilex pubescens Hook et Arn.
(6) Plantago asiatica L.
(7) Descurainia sophia (L.) Webb ex Prantl.
(8) Cinnamomum cassia Presl
(9) Ligustrum lucidum Ait.
(10) Cinnamomum cassia Presl
(1) Aconiti lateralis radix preparata
(2) Fresh Mongolian milkvetch root
(3) Salvia miltiorrhiza
(4) White peony root
(5) Pubescentholly root
(6) Plantain seed
(7) Semen descurainiae lepidii
(8) Cinnamon
(9) Glossy privet fruit
(10) Cassia twig
(1) Fuzi
(2) Huangqi
(3) Dangshen
(4) Baishao
(5) Maodongqing
(6) Cheqianzi
(7) Tinglizi
(8) Rougui
(9) Nvzhenzi
(10) Guizhi
11 g per pack

Zou [18]Nuanxin capsule(1) Panax ginseng C.A. Mey.
(2) Aconitum carmichaelii Debx.
(3) Coix lacryma-jobi L.var.ma-yuen (Roman.) Stapf
(4) Poria cocos (Schw.) Wolf
(5) Pinellia ternate (Thunb.) Breit.
(6) Citrus reticulata Blanco and Citrus reticulate “dahongpao” or Citrus reticulata Blanco “Tangerina”
(7) Panax notoginseng (Burk.) F. H. Chen
(1) Radix ginseng rubra
(2) Aconiti lateralis radix preparata
(3) Coix seed
(4) Tuckahoe
(5) Rhizoma Pinelliae Preparata
(6) Tangerine peel
(7) Sanchi
(1) Hongshen
(2) Shufuzi
(3) Yiyiren
(4) Fuling
(5) Fabanxia
(6) Juhong
(7) Sanqi
0.45 g per capsule

Liu et al. [20]Nuanxin capsule(1) Panax ginseng C.A. Mey.
(2) Aconitum carmichaelii Debx.
(3) Coix lacryma-jobi L.var.ma-yuen (Roman.) Stapf
(4) Poria cocos (Schw.) Wolf
(5) Pinellia ternate (Thunb.) Breit.
(6) Citrus reticulata Blanco and Citrus reticulate “Dahongpao”
Or Citrus reticulata Blanco “Tangerina”
(7) Panax notoginseng (Burk.) F.H. Chen
(1) Radix ginseng rubra
(2) Aconiti lateralis radix preparata
(3) Coix seed
(4) Tuckahoe
(5) Rhizoma Pinelliae Preparata
(6) Tangerine peel
(7) Sanchi
(1) Hongshen
(2) Shufuzi
(3) Yiyiren
(4) Fuling
(5) Fabanxia
(6) Juhong
(7) Sanqi
0.45 g per capsule

Wang [21]Tongyang Huoxue granule(1) Aconitum carmichaelii Debx.
(2) Zingiber officinale Rosc.
(3) Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao and Astragalus membranaceus (Fisch.) Bge.
(4) Salvia miltiorrhiza Bge.
(1) Aconiti lateralis radix preparata
(2) Zingiberis Rhizoma
(3) Fresh Mongolian milkvetch root
(4) Salvia miltiorrhiza
(1) Paofuzi
(2) Ganjiang
(3) Huangqi
(4) Danshen
9 g per granule

Cao et al. [22]Kangshuai oral solution(1) Panax ginseng C.A. Mey.
(2) Aconitum carmichaelii Debx.
(3) Salvia miltiorrhiza Bge.
(4) Acanthopanax gracilistylus W. W. Smith
(1) Ginseng radix et rhizoma
(2) Aconiti lateralis radix preparata
(3) Salvia miltiorrhiza
(4) Acanthopanacis Cortex
(1) Renshen
(2) Fupian
(3) Danshen
(4) Wujiapi
Not mentioned

Zou et al. [23]Nuanxin capsule(1) Panax ginseng C.A. Mey.
(2) Aconitum carmichaelii Debx.
(3) Coix lacryma-jobi L.var.ma-yuen (Roman.)Stapf
(4) Poria cocos (Schw.) Wolf
(5) Pinellia ternate (Thunb.) Breit.
(6) Citrus reticulata Blanco and Citrus reticulate “Dahongpao”
Or Citrus reticulata Blanco “Tangerina”
(7) Panax notoginseng (Burk.) F.H. Chen
(1) Radix ginseng rubra
(2) Aconiti lateralis radix preparata
(3) Coix seed
(4) Tuckahoe
(5) Rhizoma Pinelliae Preparata
(6) Tangerine peel
(7) Sanchi
(1) Hongshen
(2) Shufuzi
(3) Yiyiren
(4) Fuling
(5) Fabanxia
(6) Juhong
(7) Sanqi
0.45 g per capsule
Li et al. [24]Qili qiangxin capsule(1) Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao and Astragalus membranaceus (Fisch.) Bge.
(2) Panax ginseng C.A. Mey.
(3) Aconitum carmichaelii Debx.
(4) Salvia miltiorrhiza Bge.
(5) Descurainia sophia (L.) Webb.ex Prantl.
(6) Rhizoma alismatis
(7) Alisma orientalis (Sam.) Juzep.
(8) Polygonatum odoratum (Mill.) Druce
(9) Carthamus tinctorius L.
(10) Periploca sepium Bge.
(11) Citrus reticulata Blanco and Citrus reticulate “Chachi”
Or Citrus reticulate “Dahongpao” or Citrus reticulata “Unshiu”
Or Citrus reticulata “Tangerina”
(1) Fresh Mongolian milkvetch root
(2) Ginseng radix et rhizoma
(3) Aconiti lateralis radix preparata
(4) Salvia miltiorrhiza
(5) Semen descurainiae lepidii
(6) Alismatis rhizoma
(7) Polygonati odotati rhizoma
(8) Cinnamomi ramulus
(9) Carthami flos
(10) Periploca cortex
(11) Citri reticulatae pericarpium
(1) Haungqi
(2) Renshen
(3) Heishunpian
(4) Danshen
(5) Tinglizi
(6) Zexie
(7) Yuzhu
(8) Guizhi
(9) Honghua
(10) Xiangjiapi
(11) Chenpi
0.3 g per capsule

Dong [25]Shenfu qiangxin pill(1) Panax ginseng C.A. Mey.
(2) Aconitum carmichaelii Debx.
(3) Descurainia sophia (L.) Webb.ex Prantl.
(4) Morus alba L.
(5) Rheum palmatum L.and Rheum tanguticum Maxim.ex Balf.
and Rheum officinale Braill.
(6) Polyporus umbellatus (Pers.) Fries
(1) Ginseng radix et rhizoma
(2) Aconiti lateralis radix preparata
(3) Semen descurainiae lepidii
(4) Mori Cortex
(5) Rhei Radix et Rhizoma
(6) Polyporus
(1) Renshen
(2) Fuzi
(3) Tinglizi
(4) Sangbaipi
(5) Dahuang
(6) Zhuling
3 g per pill

Li et al. [26]Baoyuan shipi decoction(1) Panax ginseng C.A. Mey.
(2) Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao and Astragalus membranaceus (Fisch.) Bge.
(3) Glycyrrhiza uralensis Fisch. Glycyrrhiza inflate Bat.
Glycyrrhiza glabra L.
(4) Magnolia officinalis Rehd.et Wils. or Magnolia officinalis Rehd.et Wils.Var.bilobaReld.et Wils.
(5) Atractylodes macrocephala Koidz
(6) Chaenomeles speciose (sweet) Nakai
(7) Amomum tsao-ko Crevost et Lemaire
(8) Areca catechu L.
(9) Aconitum carmichaelii Debx.
(10) Poria cocos (Schw.) Wolf
(11) Zingiber officinale Rosc.
(1) Ginseng radix et rhizoma
(2) Fresh Mongolian milkvetch root
(3) Radix glycyrrhizae prepared
(4) Magnoliae Officmalis Cortex
(5) Large head Atractylodes Rhizome
(6) Chaenomelis Fructus
(7) Fructus Tsaoko
(8) Betelnut peel
(9) Aconiti lateralis radix preparata
(10) Tuckahoe
(11) Zingiberis Rhizoma
(1) Renshen
(2) Huangqi
(3) Zhigancao
(4) Houpu
(5) Baizhu
(6) Mugua
(7) Caoguoren
(8) Dafupi
(9) Fuzi
(10) Fuling
(11) Ganjiang
Not mentioned

Wei [27]Wenyang lishui decoction(1) Ginseng radix et rhizoma
(2) Poria cocos (Schw.) Wolf
(3) Cinnamomum cassia Presl
(4) Aconitum carmichaelii Debx.
(5) Atractylodes macrocephala Koidz
(6) Crataegus pinnatifida Bge.var.major N.E.Br.or Crataegus pinnatifida Bge.
(7) Salvia miltiorrhiza Bge.
(8) Glycyrrhiza uralensis Fisch. Glycyrrhiza inflate Bat.
Glycyrrhiza glabra L.
(1) Radix Salviae Miltiorrhizae
(2) Tuckahoe
(3) Cinnamomi ramulus
(4) Typhonii Rhizoma
(5) Rhizoma artactylodis macrocephalae
(6) Hawthorn fruit
(7) Salvia miltiorrhiza
(8) Radix Rhizoma Glycyrrhizae
(1) Shengshaishen
(2) Fuling
(3) Guizhi
(4) Baifupian
(5) Chaobaizhu
(6) Shanzha
(7) Danshen
(8) Shenggancao
15
15
15
15
15
20
20
5g
Zhu [28]Yiqi qiangxin decoction(1) Codonopsis pilosula (Franch.) Nannf.
Or Codonopsis pilosula Nannf.var.modesta (Nannf.) L.T. Shen
Or Codonopsis tangshen Oliv.
(2) Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao and Astragalus membranaceus (Fisch.) Bge.
(3) Angelica sinensis (Oliv.) Diels
(4) Pheretima aspergillum (E. Perrier) or Pheretima vulgaris Chen
Or Pheretima guillelmi (Michaelsen) or Pheretima pectinifera Michaelsen
(5) Crataegus pinnatifida Bge.var.major N.E.Br. or Crataegus pinnatifida Bge.
(6) Poria cocos (Schw.) Wolf
(7) Glycyrrhiza uralensis Fisch. and Glycyrrhiza inflate Bat. and Glycyrrhiza glabra L.
(8) Leonurus japonicus Houtt.
(9) Aconitum carmichaelii Debx.
(10) Paeonia lactiflora Pall.
(11) Descurainia sophia (L.) Webb.ex Prantl.
(12) Salvia miltiorrhiza Bge.
(1) Root of Pilose Asiabell
(2) Fresh Mongolian milkvetch root
(3) Angelicae Sinensis Radix
(4) Pheretima
(5) Rhizoma artactylodis macrocephalae
(6) Tuckahoe
(7) Radix glycyrrhizae prepared
(8) Herba Leonuri
(9) Aconiti lateralis radix preparata
(10) White peony root
(11) Semen descurainiae lepidii
(12) Salvia miltiorrhiza
(1) Dangshen
(2) Shenghuangqi
(3) Danggui
(4) Dilong
(5) Chaobaizhu
(6) Fuling
(7) Zhigancao
(8) Yimucao
(9) Fuzi
(10) Baishao
(11) Tinglizi
(12) Danshen
30
50
20
20
20
20
15
20
15
20
15
20

Wang et al. [29]SFJ(1) Panax ginseng C.A. Mey.
(2) Aconitum carmichaelii Debx.
(1) Ginseng radix et rhizome
(2) Aconiti lateralis radix preparata
(1) Renshen
(2) Fuzi
Not mentioned

SFJ = Shenfu injection.