Chaihu-Shugan-San Reinforces CYP3A4 Expression via Pregnane X Receptor in Depressive Treatment of Liver-Qi Stagnation Syndrome

Figure 4

Effect of CSS on CYP450 proteins and mRNAs in the LSSD depression model after 4 weeks of constraint stress, overfatigue, and an improper diet. (a) Effects of CSS on CYP450 proteins in the LSSD depression model after 4 weeks of constraint stress, overfatigue, and an improper diet with 2 weeks of CSS treatment. (b–f) Effects of CSS on the proteins (colour: blank) and mRNAs (colour: red) of CPY450 (CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4) in the LSSD depression model with 2 weeks of CSS treatment. , , , compared with the depression model group.