Research Article

Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula

Table 1

The information of disease-related targets.

UniProt-IDProtein namesGene namesDegree

P03372Estrogen receptorESR125
P04150Glucocorticoid receptorNR3C113
P05067Amyloid-beta A4 proteinAPP15
P06401Progesterone receptorPGR4
P06746DNA polymerase betaPOLB4
P10275Androgen receptorAR27
P10636Microtubule-associated protein tauMAPT13
P11413Glucose-6-phosphate 1-dehydrogenaseG6PD13
P11473Vitamin D3 receptorVDR13
P37231Peroxisome proliferator-activated receptor gammaPPARG23
Q08828Adenylate cyclase type 1ADCY112
Q13887Krueppel-like factor 5KLF51
Q9NYA1Sphingosine kinase 1SPHK13
Q9UBM77-dehydrocholesterol reductaseDHCR714
P00915Carbonic anhydrase 1CA16
P00918Carbonic anhydrase 2CA217
P04798Cytochrome P450 1A1CYP19A111
Q079731,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialCYP24A15
Q92731Estrogen receptor betaESR218
O15439Multidrug resistance-associated protein 4ABCC44
O15118NPC intracellular cholesterol transporter 1NPC14
Q96RI1Bile acid receptorNR1H44
Q12908Ileal sodium/bile acid cotransporterSLC10A26
P51449Nuclear receptor ROR-gammaRORC4
O75751Solute carrier family 22 member 3SLC22A35
P04278Sex hormone-binding globulinSHBG5
Q12772Sterol regulatory element-binding protein 2SREBF24
P02774Vitamin D-binding proteinGC2
O95622Adenylate cyclase type 5ADCY513
P04798Cytochrome P450 1A1CYP1A112
P05091Aldehyde dehydrogenase, mitochondrialALDH211
P05177Cytochrome P450 1A2CYP1A210
P07900Heat shock protein HSP 90-alphaHSP90AA116
P09917Arachidonate 5-lipoxygenaseALOX513
P11309Serine/threonine-protein kinase pim-1PIM115
P18031Tyrosine-protein phosphatase non-receptor type 1PTPN118
P19438Tumor necrosis factor receptor superfamily member 1ATNFRSF1A9
P23219Prostaglandin G/H synthase 1PTGS114
P24941Cyclin-dependent kinase 2CDK214
P33527Multidrug resistance-associated protein 1ABCC114
P35228Nitric oxide synthase, inducibleNOS218
P35354Prostaglandin G/H synthase 2PTGS219
P36888Receptor-type tyrosine-protein kinase FLT3FLT37
P47989Xanthine dehydrogenase/oxidase (includes xanthine dehydrogenase)XDH12
P48736Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformPIK3CG9
P49841Glycogen synthase kinase-3 betaGSK3B15
P68400Casein kinase II subunit alphaCSNK2A14
Q00534Cyclin-dependent kinase 6CDK612
Q12791Calcium-activated potassium channel subunit alpha-1KCNMA14
Q12882Dihydropyrimidine dehydrogenase [NADP(+)]DPYD4
Q16539Mitogen-activated protein kinase 14MAPK1415
Q16678Cytochrome P450 1B1CYP1B114
Q9BVA1Tubulin beta-2B chainTUBB2B15
Q9UNQ0ATP-binding cassette subfamily G member 2ABCG213
Q9Y263Phospholipase A-2-activating proteinPLAA12
P00519Tyrosine-protein kinase ABL1ABL17
P35869Aryl hydrocarbon receptorAHR8
O43570Carbonic anhydrase 12CA1218
P51679C-C chemokine receptor type 4CCR410
P13569Cystic fibrosis transmembrane conductance regulatorCFTR2
P16220Cyclic AMP-responsive element-binding protein 1CREB112
P53355Death-associated protein kinase 1DAPK111
P60568Interleukin-2IL218
P51812Ribosomal protein S6 kinase alpha-3RPS6KA311
P43405Tyrosine-protein kinase SYKSYK4
Q04760Lactoylglutathione lyaseGLO115
P08183Multidrug resistance protein 1ABCB112
P14174Macrophage migration inhibitory factorMIF3
P15559NAD(P)H dehydrogenase [quinone] 1NQO16
O14746Telomerase reverse transcriptaseTERT11
P02766TransthyretinTTR12
P15692Vascular endothelial growth factor AVEGFA17
P00734ProthrombinF29
P08514Integrin alpha-IIbITGA2B2
P08842Steryl-sulfataseSTS3
P15090Fatty acid-binding protein, adipocyteFABP42
P282235-hydroxytryptamine receptor 2AHTR2A8
Q16790Carbonic anhydrase 9CA98
P05230Fibroblast growth factor 1FGF17
P09038Fibroblast growth factor 2FGF27
P10145Interleukin-8CXCL81
P09382Galectin-1LGALS12
P17931Galectin-3LGALS34
P01112GTPase HRasHRAS1
P14679TyrosinaseTYR9
P0825372 kDa type IV collagenaseMMP24
P08254Stromelysin-1MMP34
P09874Poly [ADP-ribose] polymerase 1PARP12
P14780Matrix metalloproteinase-9MMP94
P24864G1/S-specific cyclin-E1CCNE14
P39900Macrophage metalloelastaseMMP124
O60285NUAK family SNF1-like kinase 1NUAK16
P37840Alpha-synucleinSNCA5
P11712Cytochrome P450 2C9CYP2C93
P51684C-C chemokine receptor type 6CCR62
P27695DNA-(apurinic or apyrimidinic site) lyaseAPEX14
P11388DNA topoisomerase 2-alphaTOP2A5
O60218Aldo-keto reductase family 1 member B10AKR1B109
P25116Proteinase-activated receptor 1F2R5
P43681Neuronal acetylcholine receptor subunit alpha-4CHRNA44
P63151Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoformPPP2R2A3
Q04206Transcription factor p65RELA3
P14867Gamma-aminobutyric acid receptor subunit alpha-1GABRA13
P06881Calcitonin gene-related peptide 1CALCA1
P13501C-C motif chemokine 5CCL51
P32245Melanocortin receptor 4MC4R1
P68104Elongation factor 1-alpha 1EEF1A13
Q13822Ectonucleotide pyrophosphatase/phosphodiesterase family member 2ENPP23
Q9Y251HeparanaseHPSE3
P53985Monocarboxylate transporter 1SLC16A12
P11509Cytochrome P450 2A6CYP2A63
Q15788Nuclear receptor coactivator 1NCOA11
Q99814Endothelial PAS domain-containing protein 1EPAS13
P00533Epidermal growth factor receptorEGFR4
Q16665Hypoxia-inducible factor 1-alphaHIF1A2
P40926Malate dehydrogenase, mitochondrialMDH22