Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review
Table 3
Characteristics of included studies.
First author
Year
Country
Study design
Inclusion criteria
Intervention
Study subject
Mean age (years)
Gender (M/F)
Race
BMI
Outcome measures
Jacob
2003
USA
Follow-up study
Screened for good health by a medical history questionnaire, physical exam, and standardized blood and urine tests; including a complete blood cell count with leukocytes differentials, clinical chemistry panel, urinalysis, and tests for infectious diseases
Through consumption of two servings (280 g) of cherries after an overnight fast
10 healthy women
29.9 ± 6.1(range: 22–40)
0/10
Primarily caucasian
NA
Plasma urate decreased significantly over the 5 h period after cherry consumption, and the concentration at 5 h post-dose was significantly lower than at the baseline
Schlesinger
2012
USA
Randomized controlled trial (RCT)
Patients with monosodium urate (MSU) crystal-proven gout
The case and control group received a tablespoon of juice concentrate twice a day, with an intervention period of 4 months
Case-cherry juice (n = 9) Control-pomegranate juice (n = 5)
Overall, serum urate levels were only slightly reduced following treatment with either cherry juice (from 8.37 ± 0.82 to 8.17 ± 1.1 mg/dL) or pomegranate juice (from 7.45 ± 1.62 to 6.14 ± 1.07 mg/dL)
Zhang
2012
USA
Case-crossover study
Gout diagnosed by a physician and that have suffered a gout attack within the past 12 months
Single blind, two-phase, randomized, crossover design
Volunteered for the study; all volunteers confirmed they were nonsmokers, had no known food allergies, and no history of gastrointestinal, renal, or cardiovascular disease or use of food supplementations
The bioavailability of anthocyanins followed by the ingestion of two different doses of montmorency tart cherry juice concentrate (MC)
12 healthy participants
26 ± 3
11/1
NA
NA
Serum urate displayed effects after a significant amount of time (F (1, 8) = 10.626, )
Singh
2015
USA
Retrospective cohort study
293 internet survey respondents 220 (75%) with gout 61 (21%)W/O gout 12 (4%) no response
Cherry intake (1 month)
220 gout patients
55.2 ± 14.1
74%/26%
White: 79%
Cherry intake has significantly stronger effects in producing less number of gout flare vs. none (1.54 vs. 1.91, )
Participants were aged ≥18 y, not pregnant, not diabetic, with no unresolved infections or diseases (diabetes, cardiovascular disease, inflammatory bowel disease, cancer, or liver disease), and nonsmokers
Through consumption of 240 mL/d of either tart cherry juice (TCJ) or placebo beverage
26 participants (overweight and obese participants with body mass index (BMI) > 25.0 kg/m2)
41 ± 11 (range 22–61 y)
8/18
NA
Mean ± SE 31.3 ± 6.3 (range 25.1–51.3)
TCJ significantly reduced serum uric acid concentration by 19.2% ()