Evidence-Based Complementary and Alternative Medicine

Research Article

Identifying Synergistic Mechanisms of Multiple Ingredients in Shuangbai Tablets against Proteinuria by Virtual Screening and a Network Pharmacology Approach

Table 2

The information of the top 16 active ingredients with the herb number exceeding 8.
CompoundMol IDTargets categoryHerbs
MOL000358Beta-sitosterol15 kinds, NR3C1, HSD11B2, PPARA, etc.ABR, IRH, PRA, RPR, STR, FRU, DRA, LHE, TME
MOL000098Quercetin11 kinds, DPP4, PPARA, PTGS2, etc.HMM, PPL
MOL001454Berberine11 kinds, PTGS2, ALOX5AP, ICAM1, etc.ABR
MOL008006Paryriogenin A11 kinds, NR3C1, ACE, NOS2, etc.TME
MOL002897Epiberberine11 kinds, PTGS2, ESR1, ZAP70, etc.ABR
MOL000296Hederagenin11 kinds, ALOX5AP, LYZ, NOS2, etc.ASE, HMM, LHE
MOL0003787-O-Methylisomucronulatol10 kinds, DPP4, GUSB, RET, etc.IRH, HMM
MOL012542β-Ecdysterone10 kinds, AGTR1, NR3C2, TNF, etc.ABR
MOL001494Mandenol9 kinds, PPARA, PTGS2, FLT1, etc.CRH
MOL000519Coniferin8 kinds, AGTR1, ESR1, PTGS2, etc.ASE, FRU, SWH
MOL000422Kaempferol8 kinds, ICAM1, HMOX1, DPP4, etc.RPA, PPL, HMM, CSR, ABR
MOL000211Mairin8 kinds, ALOX5AP, CD81, NOS2, etc.RPA, PPL, HMM
MOL002875Methyl oleate8 kinds, PPARA, PTGS2, HSD11B2, etc.ASE
MOL000359Sitosterol8 kinds, ESR1, HSD11B1, NR3C2, etc.SWH, RPA, RPR, CRH, FRU
MOL000449Stigmasterol8 kinds, PTGS2, ESR1, NOS2, etc.IRH, RPR, ABR
MOL002157Wallichilide8 kinds, CTSL, ACE, CTSB, etc.CRH